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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for January 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.<\/p>\n
In Situ Vaccine Uses Immune Response to Treat Cancer<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — In situ vaccination is an approach that can trigger an immune response in a manner that is specific to the tumor antigens to treat malignancy, according to a study published online Jan. 31 in Science Translational Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Tisagenlecleucel Beneficial for Youth With Refractory B-Cell ALL<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — A single infusion of the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, tisagenlecleucel, provides durable remission in pediatric and young adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL), according to a study published in the Feb. 1 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Glecaprevir-Pibrentasvir Effective Treatment for HCV Genotypes 1, 3<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — Once-daily treatment with glecaprevir-pibrentasvir appears safe and effective for the treatment of hepatitis C virus (HCV) genotype 1 or 3, according to a study published in the Jan. 25 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Top Three Challenges Identified for Pharmacists in 2018<\/font><\/p>\n TUESDAY, Jan. 30, 2018 (HealthDay News) — The top pharmacy challenges for 2018 are drug affordability, nonadherence, and pharmacist compensation, according to a report published online Jan. 7 in Managed Healthcare Executive<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Statin, BP Lowering Meds Don’t Impact Erectile Function<\/font><\/p>\n TUESDAY, Jan. 30, 2018 (HealthDay News) — For older men with at least one cardiovascular risk factor, treatment with statin and\/or pharmacologic blood pressure reduction does not significantly impact erectile function, according to a study published in the January issue of the Canadian Journal of Cardiology<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Glucagon Underutilized in Prehospital, Emergency Settings<\/font><\/p>\n TUESDAY, Jan. 30, 2018 (HealthDay News) — Glucagon is being underutilized in the prehospital and outpatient setting, according to a research letter published recently in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Regulators Trying to Reduce Physician Burden Linked to EHR<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — The Office of the National Coordinator for Health Information Technology (ONC) is trying to address some of the issues relating to physician electronic health record (EHR) burden, partly with the appointment of Don Rucker, M.D., who is skilled in informatics and board-certified in emergency and internal medicine, according to an article published in Medical Economics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Pharmacist Education May Cut Junior Doctor Prescription Errors<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — Pharmacist feedback and education is effective at reducing prescription writing errors by junior doctors in an inpatient setting, according to a study published online Jan. 24 in the Journal of Pharmacy Practice and Research<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Health Care Spending Up, Mainly Due to Rising Prices<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — Americans under age 65 years who were insured through their employer spent more than ever before on health care in 2016, with faster spending growth in 2016 than in recent years, according to the Health Care Cost Institute (HCCI)’s annual Health Care Cost and Utilization Report<\/i>.<\/p>\n More Information<\/a><\/p>\n FDA Approves Lutathera for Some Gastro and Pancreatic Cancers<\/font><\/p>\n FRIDAY, Jan. 26, 2018 (HealthDay News) — Lutathera (lutetium Lu 177 dotatate) is the first radioactive drug to be approved by the U.S. Food and Drug Administration to treat somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), the agency said Friday in a news release.<\/p>\n More Information<\/a><\/p>\n Solanezumab Doesn’t Affect Cognitive Decline in Alzheimer’s<\/font><\/p>\n FRIDAY, Jan. 26, 2018 (HealthDay News) — For patients with mild Alzheimer’s disease, solanezumab administered every four weeks does not alter cognitive decline, according to a study published in the Jan. 25 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Biomarkers Help Identify CHF Patients Needing Med Titration<\/font><\/p>\n THURSDAY, Jan. 25, 2018 (HealthDay News) — Using biomarkers to identify heart failure patients for up-titration of medications may improve mortality and hospitalization rates, according to a study published in the Jan. 30 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Cannabidiol Efficacious for Lennox-Gastaut Drop Seizures<\/font><\/p>\n THURSDAY, Jan. 25, 2018 (HealthDay News) — For patients with drop seizures associated with Lennox-Gastaut syndrome, add-on cannabidiol is associated with a reduction in monthly drop seizure frequency, according to a study published online Jan. 24 in The Lancet<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Adjunct Zonisamide Beneficial in Dementia With Lewy Bodies<\/font><\/p>\n WEDNESDAY, Jan. 24, 2018 (HealthDay News) — For patients with dementia with Lewy bodies (DLB), zonisamide as an adjunct to levodopa therapy improves parkinsonism, according to a study published online Jan. 24 in Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Prescribing of Opioids Adds to Patient Satisfaction With Care<\/font><\/p>\n WEDNESDAY, Jan. 24, 2018 (HealthDay News) — Patients with musculoskeletal conditions who are using prescribed opioids are more likely to be highly satisfied with their care, according to a study published in the January\/February issue of the Annals of Family Medicine<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Anti-Thyroid Rx Exposure Ups Risk of Congenital Malformations<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Exposure to anti-thyroid drugs (ATDs) during the first trimester of pregnancy is associated with increased risk of congenital malformations, according to a study published online Jan. 23 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Available Evidence on Marijuana’s Cardiovascular Effects Is Scant<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — The evidence examining associations between marijuana use and cardiovascular risk factors and outcomes is limited, according to a review published online Jan. 23 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Out-of-Pocket Expenditures Down With ACA Implementation<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Implementation of the Affordable Care Act (ACA) was associated with reduced out-of-pocket spending, although increases were noted in mean premium spending, according to a study published online Jan. 22 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n New ACC\/AHA Recs Developed for BP Evaluation, Management<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — New recommendations have been developed for the prevention, detection, evaluation, and management of high blood pressure (BP). The recommendations are summarized in an article published online Jan. 23 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Ideas and Opinions (subscription or payment may be required)<\/a><\/p>\n Walmart Launches Disposal Solution for Opioids, Rx Meds<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — Walmart is launching a first-of-its-kind opioid disposal solution in all company pharmacies, which is available at no cost, according to a press release from the company.<\/p>\n More Information<\/a><\/p>\n ADHD Meds Increasingly Prescribed to Reproductive-Aged Women<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — Reproductive-aged women are increasingly being prescribed attention-deficit\/hyperactivity disorder (ADHD) medications, according to research published in the Aug. 25 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Confusion Common in Seniors Prescribed Antibiotics for UTI<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — Urinary tract infections (UTIs) are common in nursing home (NH) residents, and new or worsening confusion is strongly associated with antibiotic treatment for suspected UTI, according to a study published online Jan. 10 in the Journal of the American Geriatrics Society<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Greater Prior Authorization Requirements Seen for PCSK9i Rx<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — Prior authorization (PA) requirements are greater for proprotein convertase subtilisin\/kexin type 9 inhibitors (PCSK9is) than for other cardiometabolic drugs, according to a study published online Jan. 11 in Circulation: Cardiovascular Quality and Outcomes<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Anticoagulation Guidance Issued for Cardiopulmonary Bypass<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — Clinical practice guidelines for anticoagulation therapy for cardiopulmonary bypass (CPB) have been developed and were published in the February issue of the Annals of Thoracic Surgery<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Brochure Can Improve Opioid Disposal Rates After Surgery<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — Disseminating an educational brochure improves disposal of unused opioids after surgery, according to a study published online Jan. 10 in the Journal of the American College of Surgeons<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n LDL-C Still High in Autosomal Recessive Hypercholesterolemia<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — For patients with autosomal recessive hypercholesterolemia (ARH), low-density lipoprotein cholesterol (LDL-C) levels remain high despite intensive treatment, according to a study published in the Jan. 23 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Reminder, Recall Systems Improve Immunization Uptake<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — Patient reminder and recall systems seem to be effective for improving receipt of immunizations, according to a review published online Jan. 18 in the Cochrane Library<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Pharmacist Participation in Stroke Response Cuts Door\u279cNeedle Time<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — Having a pharmacist at bedside during acute ischemic stroke is associated with significantly shorter door-to-needle (DTN) times, according to a study published recently in the Annals of Pharmacotherapy<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Longer Duration of Post-Op Opioid Use Associated With Misuse<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — Each refill and week of opioid prescription following surgery is associated with an increasing risk of opioid misuse among opioid naive patients, according to a study published online Jan. 17 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Onabotulinum Toxin-A Can Safely Improve Sleep Bruxism<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — Onabotulinum toxin-A (BoNT-A) injections can improve sleep bruxism, according to a study published online Jan. 17 in Neurology<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Increased Risk of Complications With Bariatric Surgery<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — Bariatric surgery is associated with lower risks of obesity-related comorbidities but a clinically important increased risk for complications compared with medical treatment, according to a study published in the Jan. 16 issue of the Journal of the American Medical Association<\/i>, a theme issue on obesity.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Value of Doxylamine-Pyridoxine Questioned in Early Pregnancy<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — Doxylamine-pyridoxine may be beneficial for nausea and vomiting symptoms in early pregnancy, but the magnitude of the difference is very small and may indicate no clinically important benefit, according to a study published online Jan. 17 in PLOS ONE<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Sulfonamides, Nitrofurantoin Being Given for UTI in Pregnancy<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — For women with urinary tract infections (UTIs), the most frequently prescribed antibiotics during the first trimester are nitrofurantoin, ciprofloxacin, cephalexin, and trimethoprim-sulfamethoxazole, according to research published in the Jan. 12 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Psoriasis Remission Described After Hepatitis C Virus Treatment<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — A case of remission of psoriasis after treatment of chronic hepatitis C virus (HCV) has been described in a research letter published online Jan. 16 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n High Response of Desmoplastic Melanomas to PD-1 Blockade<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — Patients with desmoplastic melanoma have a high level of objective tumor response to treatment with antibodies to block programmed cell death 1 (PD-1) or PD-1 ligand (PD-L1), according to a study published online Jan. 10 in Nature<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Color-Coded Drug Storage Trays May Cut Medication Errors<\/font><\/p>\n TUESDAY, Jan. 16, 2018 (HealthDay News) — Color-coded compartmentalized “rainbow trays” used for anesthetic drug preparation and storage may improve patient safety, according to a study published online Jan. 3 in Anaesthesia<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n FDA OKs Lynparza to Treat Breast Cancer With BRCA<\/i> Mutation<\/font><\/p>\n FRIDAY, Jan. 12, 2018 (HealthDay News) — Lynparza (olaparib) has been approved by the U.S. Food and Drug Administration to treat metastatic breast cancer caused by a BRCA<\/i> gene mutation.<\/p>\n More Information<\/a><\/p>\n Ceramide-Infused Skin Barrier Cuts Stoma-Related Costs<\/font><\/p>\n FRIDAY, Jan. 12, 2018 (HealthDay News) — Use of a ceramide-infused ostomy skin barrier is associated with reduced stoma-related cost of care, according to a study published in the January\/February issue of the Journal of Wound, Ostomy and Continence Nursing<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Considerable Economic Burden for Asthma in United States<\/font><\/p>\n FRIDAY, Jan. 12, 2018 (HealthDay News) — Asthma places a considerable economic burden on the United States, with a total cost of $81.9 billion in 2013, according to a study published online Jan. 12 in the Annals of the American Thoracic Society<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Tamper-Resistant Oxycodone Misused Less Often in Australia<\/font><\/p>\n FRIDAY, Jan. 12, 2018 (HealthDay News) — The tamper-resistant formulation of controlled-release oxycodone in Australia reduced tampering among high-risk populations, according to a study published online Jan. 10 in The Lancet Psychiatry<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Treatment of Urgency Urinary Incontinence Aids Sleep Quality<\/font><\/p>\n FRIDAY, Jan. 12, 2018 (HealthDay News) — Pharmacologic treatment of urgency urinary incontinence (UUI) improves sleep quality, according to research published online Jan. 9 in Obstetrics & Gynecology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Progress in Fighting Antibiotic Resistance Shown in CDC Map<\/font><\/p>\n THURSDAY, Jan. 11, 2018 (HealthDay News) — The U.S. Centers for Disease Control and Prevention has released new data in its Antibiotic Resistance Investment Map, which shows states’ progress in combating antibiotic resistance.<\/p>\n Press Release<\/a><\/p>\n Prenatal PPI, H2 Blocker Use Linked to Asthma Risk in Child<\/font><\/p>\n THURSDAY, Jan. 11, 2018 (HealthDay News) — Prenatal, maternal, acid-suppressive drug use is associated with an increased risk of childhood asthma, according to a review published online Jan. 11 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Race, Education Level Predict CRT in Very Elderly With NSCLC<\/font><\/p>\n THURSDAY, Jan. 11, 2018 (HealthDay News) — In patients aged 80 and older with advanced non-small-cell lung cancer (NSCLC), overall survival is improved with concurrent chemoradiation therapy (CRT), but black race and lower-educated census tract are associated with not receiving care, according to a study published online Jan. 8 in Cancer<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Acetaminophen Use in Pregnancy Linked to Language Delay<\/font><\/p>\n THURSDAY, Jan. 11, 2018 (HealthDay News) — Acetaminophen (acetyl-para-aminophenol [APAP]) use in pregnancy is associated with language delay among girls, according to a study published online Jan. 10 in European Psychiatry<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Neurodevelopment Not Impacted by Glucocorticoids in Preemies<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — Use of inhaled glucocorticoids in extremely preterm infants for the prevention of bronchopulmonary dysplasia does not lead to a higher rate of neurodevelopmental disability at 2 years, according to a study published in the Jan. 11 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Some Patients Would Choose Antibiotics for Appendicitis<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — Although most patients would choose surgical intervention for treatment of acute uncomplicated appendicitis, some would opt for antibiotics alone, according to a study published online Jan. 10 in JAMA Surgery<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n School-Based Telemedicine Asthma Management Is Effective<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — A School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) program can improve symptoms for children with persistent asthma, according to a study published online Jan. 8 in JAMA Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Vitamin D3<\/sub> Improves Arterial Stiffness in Dose-Response Way<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — For overweight African-Americans with vitamin D deficiency, arterial stiffness is improved by vitamin D3<\/sub> supplementation in a dose-response manner, according to a study published online Dec. 7 in PLOS ONE<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Barriers to Initial Chemo, Radiation for Small-Cell Lung CA<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — A considerable proportion of patients with small-cell lung cancer (SCLC) do not receive chemotherapy or radiation therapy, according to a study published online Jan. 4 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Idalopirdine May Not Improve Cognition in Mild Alzheimer’s<\/font><\/p>\n TUESDAY, Jan. 9, 2018 (HealthDay News) — The use of idalopirdine does not improve cognition versus placebo over 24 weeks of treatment for patients with mild-to-moderate Alzheimer’s disease (AD), according to research published in the Jan. 9 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Screening, Therapy Effect Varies by Breast CA Molecular Subtype<\/font><\/p>\n TUESDAY, Jan. 9, 2018 (HealthDay News) — The contributions of screening and treatment to decreases in breast cancer mortality vary by molecular subtype, according to a study published in the Jan. 9 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n