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Here are what the editors at HealthDay consider to be the most important developments in Pathology for January 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.<\/p>\n
History of Childhood Kidney Disease Linked to Risk of ESRD<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — A history of childhood kidney disease is associated with increased risk for end-stage renal disease (ESRD) in adulthood, according to a study published in the Feb. 1 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n In Situ Vaccine Uses Immune Response to Treat Cancer<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — In situ vaccination is an approach that can trigger an immune response in a manner that is specific to the tumor antigens to treat malignancy, according to a study published online Jan. 31 in Science Translational Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Survival Trends for Cancer Generally Increasing Worldwide<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — Worldwide, survival trends for cancer are generally increasing, although there is considerable global variation in survival rates, according to a study published online Jan. 30 in The Lancet<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n TBI Linked to Increased Dementia Risk Over Several Years<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — Traumatic brain injury (TBI) is associated with persistently increased risk of dementia, according to a study published online Jan. 30 in PLOS Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Early Alzheimer’s Tied to Rest-Activity Rhythm Fragmentation<\/font><\/p>\n TUESDAY, Jan. 30, 2018 (HealthDay News) — Preclinical Alzheimer’s disease (AD) and aging are independently associated with rest-activity rhythm fragmentation among cognitively normal adults, according to a study published online Jan. 29 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Mediterranean Diet Adherence Linked to Better IVF Performance<\/font><\/p>\n TUESDAY, Jan. 30, 2018 (HealthDay News) — For non-obese women undergoing in vitro fertilization (IVF), adherence to the Mediterranean diet (MedDiet) is associated with increased likelihood of achieving clinical pregnancy and live birth, according to a study published online Jan. 30 in Human Reproduction<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n E-Cigarette Smoke Carcinogenic to Murine Lung, Bladder<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — Electronic cigarette (e-cigarette) smoke causes damage to DNA and reduces repair activity in a mouse model and in human cells, according to a study published online Jan. 29 in the Proceedings of the National Academy of Sciences<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Case Report: Fentanyl Use Associated With Amnesia<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — Another case of unusual amnestic syndrome that includes bilateral hippocampal lesions on magnetic resonance imaging has been described in a case report published online Jan. 30 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Mortality, CVD, T2DM Risks Not Up for Living Kidney Donors<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — Living kidney donors have no increased risks for all-cause mortality, cardiovascular disease, hypertension, type 2 diabetes, or adverse psychological health outcomes, according to a review published online Jan. 30 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Regulators Trying to Reduce Physician Burden Linked to EHR<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — The Office of the National Coordinator for Health Information Technology (ONC) is trying to address some of the issues relating to physician electronic health record (EHR) burden, partly with the appointment of Don Rucker, M.D., who is skilled in informatics and board-certified in emergency and internal medicine, according to an article published in Medical Economics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Pre-Op Physical Therapy May Cut Pulmonary Complications<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — A 30-minute preoperative physical therapy session focused on breathing exercises is associated with a reduced incidence of postoperative pulmonary complications (PPCs) among patients undergoing upper abdominal surgery, according to a study published online Jan. 24 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Specific White Matter Patterns Linked to Youth Psychopathology<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — General psychopathology is a heritable trait in youth that may be detected early in life through brain structural connectivity, according to a study published online Jan. 24 in JAMA Psychiatry<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Health Care Spending Up, Mainly Due to Rising Prices<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — Americans under age 65 years who were insured through their employer spent more than ever before on health care in 2016, with faster spending growth in 2016 than in recent years, according to the Health Care Cost Institute (HCCI)’s annual Health Care Cost and Utilization Report<\/i>.<\/p>\n More Information<\/a><\/p>\n 2016 Saw Increase in Birth Defects Potentially Linked to Zika<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — From the first half of 2016 to the second half of 2016, there was an increase in the number of birth defects potentially related to Zika virus infection, according to research published in the Jan. 26 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Viewpoint<\/a><\/p>\n Diabetes Impacts Mortality in Breast Cancer Patients<\/font><\/p>\n FRIDAY, Jan. 26, 2018 (HealthDay News) — Breast cancer-specific mortality remains higher among women with diabetes who have longer diabetes duration or preexisting cardiovascular disease, according to a study published online Jan. 19 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n CDC: Many U.S. Adults Have Never Been Tested for HIV<\/font><\/p>\n THURSDAY, Jan. 25, 2018 (HealthDay News) — Almost 40 percent of women and more than 50 percent of men aged 15 to 44 years had never been tested for HIV between 2011 and 2015, according to a report published Jan. 25 by the U.S. Centers for Disease Control and Prevention’s National Center for Health Statistics.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Heart Disease, Stroke Risk Up Even Smoking 1 Cigarette\/Day<\/font><\/p>\n THURSDAY, Jan. 25, 2018 (HealthDay News) — Smoking one cigarette per day is still associated with a significant increased risk of coronary heart disease and stroke, according to research published online Jan. 24 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Multidomain Lifestyle Intervention May Aid Cognition in APOE<\/i> \u03b54 Carriers<\/font><\/p>\n THURSDAY, Jan. 25, 2018 (HealthDay News) — A multidomain lifestyle intervention seems to be beneficial for cognition in older at-risk individuals, even among apolipoprotein E (APOE<\/i>) \u03b54 carriers, according to a study published online Jan. 22 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Lung Cancer Screening More Efficient for Those at Higher Risk<\/font><\/p>\n THURSDAY, Jan. 25, 2018 (HealthDay News) — Lung cancer screening (LCS) is more effective and efficient for high-risk individuals, according to a research letter published online Jan. 22 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Cloning by Somatic Cell Nuclear Transfer Feasible in Monkeys<\/font><\/p>\n WEDNESDAY, Jan. 24, 2018 (HealthDay News) — Cloning cynomolgus monkeys (Macaca fascicularis<\/i>) is feasible by somatic cell nuclear transfer (SCNT) using fetal fibroblasts, according to a study published online Jan. 24 in Cell<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Influenza, Some Viral URIs Increase Risk of Acute MI<\/font><\/p>\n WEDNESDAY, Jan. 24, 2018 (HealthDay News) — Certain respiratory infections, especially influenza, are associated with an increased risk of acute myocardial infarction during the first seven days after respiratory specimen collection, according to a study published in the Jan. 25 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Hyperandrogenism May Affect Gut Microbiome in PCOS<\/font><\/p>\n WEDNESDAY, Jan. 24, 2018 (HealthDay News) — Hyperandrogenism may play a role in changing the gut microbiome in women with polycystic ovary syndrome (PCOS), according to a study published online Jan. 23 in the Journal of Clinical Endocrinology & Metabolism<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n CV Risks, Breast CA Recurrence Down With Exercise in Survivors<\/font><\/p>\n WEDNESDAY, Jan. 24, 2018 (HealthDay News) — Supervised aerobic and resistance exercise may improve metabolic syndrome, sarcopenic obesity, and serum biomarkers in overweight and obese survivors of breast cancer, according to a study published online Jan. 22 in the Journal of Clinical Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Next-Generation Sequencing May Be Useful in Joint Infection<\/font><\/p>\n WEDNESDAY, Jan. 24, 2018 (HealthDay News) — Next-generation sequencing may be useful for identifying causative organisms in culture-negative periprosthetic joint infection, according to a study published online Jan. 17 in The Journal of Bone & Joint Surgery<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Periodontitis in Older Adults Tied to Higher Total Cancer Risk<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Individuals with periodontitis have an increased total cancer risk, according to a study published online Jan. 12 in the Journal of the National Cancer Institute<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Diabetes Tied to Higher Rates of Serious Infection<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Patients with diabetes, particularly type 1 diabetes mellitus (T1DM), are at increased risk of serious infection, according to a study published online Jan. 12 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Closed-Head Injury May Induce TBI Even If No Concussive Sx<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Closed-head impact injuries can induce pathologic traumatic brain injury, independent of concussive signs, according to a study published online Jan. 18 in Brain<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Anti-Thyroid Rx Exposure Ups Risk of Congenital Malformations<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Exposure to anti-thyroid drugs (ATDs) during the first trimester of pregnancy is associated with increased risk of congenital malformations, according to a study published online Jan. 23 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Swallowable Device Can Test for DNA Markers of Barrett’s<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — A swallowable balloon device has been developed to obtain samples from the lower esophagus — samples which then undergo assay of combined CCNA1<\/i> and VIM<\/i> DNA methylation to detect Barrett’s esophagus metaplasia, according to a study published online Jan. 17 in Science Translational Medicine<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Drinking in Early Adulthood Tied to Later Risk for Liver Disease<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Alcohol consumption in young men is associated with an increased risk of severe liver disease later in life, according to a study published online Jan. 22 in the Journal of Hepatology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Out-of-Pocket Expenditures Down With ACA Implementation<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Implementation of the Affordable Care Act (ACA) was associated with reduced out-of-pocket spending, although increases were noted in mean premium spending, according to a study published online Jan. 22 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Older Adults Less Likely to Have Provider-Ordered Flu Testing<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — Older adults are less likely than younger adults to have provider-ordered influenza testing, according to a study published online Jan. 17 in the Journal of the American Geriatrics Society<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Nutrients in Child’s First 1,000 Days Key for Neurodevelopment<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — The provision of adequate nutrients and healthy eating during a child’s first 1,000 days is important for optimal neurodevelopment, according to an American Academy of Pediatrics policy statement published online Jan. 22 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Urinalysis Is Effective for UTIs in Younger Febrile Infants<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — For febrile infants age 60 days and younger, urinalysis is highly sensitive and specific for diagnosing urinary tract infections (UTIs), according to a study published online Jan. 16 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Breast Cancer Genetic Test Less Cost-Effective in Actual Practice<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — A gene expression profile test to predict risk of breast cancer recurrence is less cost-effective in real-world practice as compared to ideal conditions, according to a study published online Jan. 8 in the Journal of Clinical Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n LDL-C Still High in Autosomal Recessive Hypercholesterolemia<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — For patients with autosomal recessive hypercholesterolemia (ARH), low-density lipoprotein cholesterol (LDL-C) levels remain high despite intensive treatment, according to a study published in the Jan. 23 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Blood Test Found to Detect Eight Common Cancer Types<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — A multi-analyte blood test, CancerSEEK, can detect eight common cancer types, with high sensitivity and specificity, according to a study published online Jan. 18 in Science<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Alcohol Induced DNA Repair Genes Prognostic in Gastric Cancer<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — For patients with gastric cancer (GC), myeloperoxidase (MPO), transcription factor IIB-related factor 1 (BRF1), and breast cancer susceptibility genes 1 and 2 (BRCA1\/2) induced by alcohol have prognostic value, according to a study published in the February issue of The American Journal of Pathology<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Proinflammatory Diet Linked to Increased Colorectal Cancer Risk<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — Proinflammatory diets are associated with increased colorectal cancer risk for men and women, according to a study published online Jan. 18 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Increased Risk of Complications With Bariatric Surgery<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — Bariatric surgery is associated with lower risks of obesity-related comorbidities but a clinically important increased risk for complications compared with medical treatment, according to a study published in the Jan. 16 issue of the Journal of the American Medical Association<\/i>, a theme issue on obesity.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Professionals Disagree About Asking Patients About Sexuality<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — National Health Service (NHS) England recently recommended that professionals ask all patients their sexual orientation at every opportunity, although opinions are divided on whether this is appropriate, according to an article published online Jan. 17 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Mediterranean Diet May Lower Risk of Aggressive Prostate CA<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — High adherence to the Mediterranean diet is associated with a lower risk of aggressive prostate cancer, according to a study published in the February issue of The Journal of Urology<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Adding HIPEC to Cytoreductive Surgery Beneficial in Ovarian CA<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery is associated with improved outcomes in patients with stage III epithelial ovarian cancer, according to a study published in the Jan. 18 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Noninvasive Marker Tied to Diabetic Retinopathy Severity<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — Disorganization of the inner retinal layers (DRIL) is associated with morphological changes in the outer retina and worse levels of diabetic retinopathy in eyes with diabetic macular edema (DME), according to a study published online Jan. 11 in JAMA Ophthalmology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Alzheimer’s Disease Variants Linked to Brain Amyloidosis<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — Certain Alzheimer’s disease (AD) risk variants are associated with brain amyloidosis, according to a study published online Jan. 16 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Human Rhinovirus Commonly Detected in Febrile Infants<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — For febrile infants, human rhinovirus (HRV) is common, and detection does not alter risk of concomitant urinary tract infection or invasive bacterial infection, according to a study published online Jan. 17 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n High Response of Desmoplastic Melanomas to PD-1 Blockade<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — Patients with desmoplastic melanoma have a high level of objective tumor response to treatment with antibodies to block programmed cell death 1 (PD-1) or PD-1 ligand (PD-L1), according to a study published online Jan. 10 in Nature<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Brain Is Susceptible to Acute MI, Chronic Heart Failure<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — Acute myocardial infarction (MI) and chronic heart failure have effects on the brain, according to a study published in the Jan. 23 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Psoriasis Remission Described After Hepatitis C Virus Treatment<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — A case of remission of psoriasis after treatment of chronic hepatitis C virus (HCV) has been described in a research letter published online Jan. 16 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Speech Outcomes Can Be Predicted After Cochlear Implant<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — Brain areas unaffected by auditory deprivation can predict speech outcomes after cochlear implant (CI) in children, according to a study published online Jan. 15 in the Proceedings of the National Academy of Sciences of the United States of America<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Lactation Duration Linked to Reduced Incidence of Diabetes<\/font><\/p>\n TUESDAY, Jan. 16, 2018 (HealthDay News) — Lactation duration is associated with reduced incidence of diabetes, according to a study published online Jan. 16 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Rising BMI Has Slowed Improvement in U.S. Mortality<\/font><\/p>\n TUESDAY, Jan. 16, 2018 (HealthDay News) — The rate of improvement in mortality in the United States has been slowed by rising body mass index (BMI), according to a study published online Jan. 15 in the Proceedings of the National Academy of Sciences<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Increased Risk of Thrombosis in Myeloproliferative Neoplasms<\/font><\/p>\n TUESDAY, Jan. 16, 2018 (HealthDay News) — Patients with myeloproliferative neoplasms (MPNs) have increased risk of arterial thrombosis and venous thrombosis across all age groups and MPN subtypes, according to a study published online Jan. 16 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Higher CVD Risk With Early Menarche, Menopause<\/font><\/p>\n TUESDAY, Jan. 16, 2018 (HealthDay News) — Reproductive factors, including early menarche and menopause, are associated with increased cardiovascular disease (CVD) risk, according to a study published online Jan. 15 in Heart<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n