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THURSDAY, March 14, 2019 (HealthDay News) — Having affected first-degree, second-degree, or third-degree relatives (FDRs, SDRs, and TDRs) is associated with an increased risk for Alzheimer disease (AD), according to a study published online March 13 in Neurology<\/i>.<\/p>\n
Lisa A. Cannon-Albright, Ph.D., from the University of Utah School of Medicine in Salt Lake City, and colleagues used a population resource, including genealogy of Utah pioneers from the 1800s, linked to Utah death certificates to estimate relative risk for AD based on specific family history constellations.<\/p>\n
The researchers found that the risk for AD was significantly increased with having any affected first-degree relatives (one or more FDRs: relative risk [RR], 1.73; two or more FDRs: RR, 3.98; three or more FDRs: RR, 2.48; four or more FDRs: RR, 14.77). Even in the presence of affected FDRs, affected SDRs correlated with an increased risk (one FDR with two SDRs: RR, 21.29). Increased risk was also seen in TDRs (no FDR, no SDR, three or more TDRs: RR, 1.43). There was mixed evidence for differences in risk based on maternal versus paternal inheritance, with higher risks for men than women with equivalent family history.<\/p>\n
“More and more, people are increasingly seeking an estimate of their own genetic risk for Alzheimer’s disease,” Cannon-Albright said in a statement. “Our findings indicate the importance of clinicians taking a person’s full family history that extends beyond their immediate family members.”<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
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