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FRIDAY, March 8, 2019 (HealthDay News) — Women with gestational diabetes mellitus (GDM) have an increased risk fir developing cardiovascular events postpartum, according to a review published online March 7 in Diabetologia<\/i>.<\/p>\n
Caroline K. Kramer, M.D., Ph.D., from Mount Sinai Hospital in Toronto, and colleagues conducted a systematic review of observational studies that examined the correlation of GDM with subsequent cardiovascular disease (CVD). Using a random-effects model, the predictive value of GDM for future cardiovascular events was calculated. Data were included for 5,390,591 women (101,424 cardiovascular events) in a pooled analysis of nine studies.<\/p>\n
The researchers found that women with GDM had an increased risk for future cardiovascular events compared with those who did not have GDM (RR, 1.98). The rates of incident type 2 diabetes across the studies did not affect this risk in meta-regression analysis. GDM remained associated with an increased risk for future cardiovascular events when restricted to women who did not develop type 2 diabetes (RR, 1.56). In the first decade postpartum, GDM conferred a 2.3-fold increased risk for cardiovascular events (RR, 2.31).<\/p>\n
“The diagnosis of GDM should be recognized as providing a unique window into a woman’s future risk of CVD, and hence an opportunity for early risk modification and possibly prevention of the leading cause of mortality in women,” the authors write.<\/p>\n
Two authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
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