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TUESDAY, Feb. 26, 2019 (HealthDay News) — Exposure to several chemicals before and after birth appears to be associated with a decrease in lung function later in childhood, according to a study published in the February issue of The Lancet Planetary Health<\/i>.<\/p>\n
Lydiane Agier, Ph.D., from University Grenoble Alpes in France, and colleagues used data from 1,033 mother-child pairs participating in the European Human Early-Life Exposome cohort (children born between 2003 and 2009). Lung function was measured by spirometry in children at age 6 to 12 years, and 85 prenatal and 125 postnatal exposures (outdoor, indoor, chemical, and lifestyle factors) were assessed.<\/p>\n
The researchers found that in the exposome-wide association study (ExWAS), prenatal perfluorononanoate and perfluorooctanoate exposures were associated with lower forced expiratory volume in 1 second percent predicted values (FEV1<\/sub>%). Inverse distance to nearest road during pregnancy was associated with higher FEV1<\/sub>%. In addition, FEV1<\/sub>% was tied to nine postnatal exposures: copper, ethyl-paraben, five phthalate metabolites (mono-2-ethyl 5-carboxypentyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2-ethyl-5-oxohexyl phthalate, mono-4-methyl-7-oxooctyl phthalate, and the sum of di-ethylhexyl phthalate metabolites), house crowding, and facility density around schools. However, after correction for multiple testing in ExWAS, no exposure passed the significance threshold.<\/p>\n “Reducing exposure to these ubiquitous chemicals could help to prevent the development of chronic respiratory disease,” the authors write.<\/p>\n Abstract\/Full Text<\/a><\/p>\n