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Here are what the editors at HealthDay consider to be the most important developments in Pediatrics for January 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.<\/p>\n
Tisagenlecleucel Beneficial for Youth With Refractory B-Cell ALL<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — A single infusion of the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, tisagenlecleucel, provides durable remission in pediatric and young adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL), according to a study published in the Feb. 1 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n History of Childhood Kidney Disease Linked to Risk of ESRD<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — A history of childhood kidney disease is associated with increased risk for end-stage renal disease (ESRD) in adulthood, according to a study published in the Feb. 1 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Survival Trends for Cancer Generally Increasing Worldwide<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — Worldwide, survival trends for cancer are generally increasing, although there is considerable global variation in survival rates, according to a study published online Jan. 30 in The Lancet<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Air Pollution May Up Likelihood of Menstrual Irregularity<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — Exposure to air pollution during high school is associated with a slightly higher likelihood of menstrual irregularity and longer time to regularity, according to a study published online Jan. 25 in Human Reproduction<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Disordered Eating Associated With Higher HbA1c in Teens<\/font><\/p>\n WEDNESDAY, Jan. 31, 2018 (HealthDay News) — For youth with type 1 diabetes, disordered eating behaviors (DEBs) are associated with higher hemoglobin A1c but not with measures of glycemic variability, according to a study published online Jan. 25 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Early Educational Enrichment Linked to Midlife Achievement<\/font><\/p>\n TUESDAY, Jan. 30, 2018 (HealthDay News) — An educational enrichment intervention offered from preschool to third grade is associated with improved educational attainment in midlife, according to a study published online Jan. 29 in JAMA Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n CDC: Many School Children Are Not Getting Enough Sleep<\/font><\/p>\n TUESDAY, Jan. 30, 2018 (HealthDay News) — Many middle school and high school students have short sleep duration, according to research published in the Jan. 26 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Surgeon Case Experience Impacts Peds Cholecystectomy Morbidity<\/font><\/p>\n TUESDAY, Jan. 30, 2018 (HealthDay News) — High-volume general surgeons have lower morbidity rates than low-volume pediatric surgeons for laparoscopic cholecystectomy in pediatric patients, independent of pediatric volume, according to a study published online Jan. 17 in JAMA Surgery<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Regulators Trying to Reduce Physician Burden Linked to EHR<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — The Office of the National Coordinator for Health Information Technology (ONC) is trying to address some of the issues relating to physician electronic health record (EHR) burden, partly with the appointment of Don Rucker, M.D., who is skilled in informatics and board-certified in emergency and internal medicine, according to an article published in Medical Economics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Specific White Matter Patterns Linked to Youth Psychopathology<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — General psychopathology is a heritable trait in youth that may be detected early in life through brain structural connectivity, according to a study published online Jan. 24 in JAMA Psychiatry<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Health Care Spending Up, Mainly Due to Rising Prices<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — Americans under age 65 years who were insured through their employer spent more than ever before on health care in 2016, with faster spending growth in 2016 than in recent years, according to the Health Care Cost Institute (HCCI)’s annual Health Care Cost and Utilization Report<\/i>.<\/p>\n More Information<\/a><\/p>\n 2016 Saw Increase in Birth Defects Potentially Linked to Zika<\/font><\/p>\n MONDAY, Jan. 29, 2018 (HealthDay News) — From the first half of 2016 to the second half of 2016, there was an increase in the number of birth defects potentially related to Zika virus infection, according to research published in the Jan. 26 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Viewpoint<\/a><\/p>\n Parental Supply of Alcohol to Adolescents Is Harmful<\/font><\/p>\n FRIDAY, Jan. 26, 2018 (HealthDay News) — Parental supply of alcohol to adolescents is associated with increased odds of alcohol-related harms, and there is no evidence to support the view that parental supply protects from adverse drinking outcomes, according to a study published online Jan. 25 in The Lancet Public Health<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n High Within-Country Economic Inequality in C-Section Rates<\/font><\/p>\n FRIDAY, Jan. 26, 2018 (HealthDay News) — In low- and middle-income countries, there is considerable within-country economic inequality in the rates of cesarean section, according to a study published online Jan. 24 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Review: Lower Cognitive Scores for HIV+, HIV-Exposed Children<\/font><\/p>\n FRIDAY, Jan. 26, 2018 (HealthDay News) — HIV-infected (HIV+) and HIV-exposed but uninfected (HEU) children have lower cognitive and motor scores than HIV-unexposed and uninfected (HUU) children, according to a review published online Jan. 26 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Cannabidiol Efficacious for Lennox-Gastaut Drop Seizures<\/font><\/p>\n THURSDAY, Jan. 25, 2018 (HealthDay News) — For patients with drop seizures associated with Lennox-Gastaut syndrome, add-on cannabidiol is associated with a reduction in monthly drop seizure frequency, according to a study published online Jan. 24 in The Lancet<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Exposure to Counties With Higher Obesity Rates Tied to Higher BMI<\/font><\/p>\n WEDNESDAY, Jan. 24, 2018 (HealthDay News) — Body mass index (BMI) and odds of overweight and\/or obesity are increased with exposure to communities with higher rates of obesity, according to a study published online Jan. 22 in JAMA Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Probiotics Tied to Lower Preterm Delivery, Preeclampsia Risk<\/font><\/p>\n WEDNESDAY, Jan. 24, 2018 (HealthDay News) — Probiotic milk consumption during pregnancy may be tied to a reduced incidence of preeclampsia and preterm delivery, according to a study published online Jan. 23 in BMJ Open<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Housing Instability Linked to Poor Caregiver, Child Health<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Housing instability is associated with adverse caregiver and child health among low-income renter households, according to a study published online Jan. 22 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Public Health Workforce to See Large Turnover<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — The public health workforce at the local and state levels will experience a significant loss of employees through 2020, due to retirement as well as other reasons for turnover, according to a study published online Jan. 11 in the American Journal of Preventive Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Diabetes Tied to Higher Rates of Serious Infection<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Patients with diabetes, particularly type 1 diabetes mellitus (T1DM), are at increased risk of serious infection, according to a study published online Jan. 12 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Available Evidence on Marijuana’s Cardiovascular Effects Is Scant<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — The evidence examining associations between marijuana use and cardiovascular risk factors and outcomes is limited, according to a review published online Jan. 23 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Closed-Head Injury May Induce TBI Even If No Concussive Sx<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Closed-head impact injuries can induce pathologic traumatic brain injury, independent of concussive signs, according to a study published online Jan. 18 in Brain<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Anti-Thyroid Rx Exposure Ups Risk of Congenital Malformations<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Exposure to anti-thyroid drugs (ATDs) during the first trimester of pregnancy is associated with increased risk of congenital malformations, according to a study published online Jan. 23 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Drinking in Early Adulthood Tied to Later Risk for Liver Disease<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Alcohol consumption in young men is associated with an increased risk of severe liver disease later in life, according to a study published online Jan. 22 in the Journal of Hepatology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Recommendations Developed for Optimizing Child Health<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — In a policy statement published online Jan. 22 in Pediatrics<\/i>, recommendations are presented for increasing cooperation between pediatricians and public health professionals in order to ensure optimal health for children.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Out-of-Pocket Expenditures Down With ACA Implementation<\/font><\/p>\n TUESDAY, Jan. 23, 2018 (HealthDay News) — Implementation of the Affordable Care Act (ACA) was associated with reduced out-of-pocket spending, although increases were noted in mean premium spending, according to a study published online Jan. 22 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n ADHD Meds Increasingly Prescribed to Reproductive-Aged Women<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — Reproductive-aged women are increasingly being prescribed attention-deficit\/hyperactivity disorder (ADHD) medications, according to research published in the Aug. 25 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Nutrients in Child’s First 1,000 Days Key for Neurodevelopment<\/font><\/p>\n MONDAY, Jan. 22, 2018 (HealthDay News) — The provision of adequate nutrients and healthy eating during a child’s first 1,000 days is important for optimal neurodevelopment, according to an American Academy of Pediatrics policy statement published online Jan. 22 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n 24-Hour Primary Care Clinics Would Improve Continuity of Care<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — A 24-hour primary care clinic with multiple doctors offering round-the-clock care would actualize better and more sustainable care, according to a report published by the American Academy of Family Physicians.<\/p>\n More Information<\/a><\/p>\n Repeat BP Reading Needed in Children With Initial High Result<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — Only approximately half of pediatric patients with a blood pressure reading \u226595th percentile would be correctly classified based on their initial blood pressure reading, according to a study published online Jan. 12 in the Journal of Clinical Hypertension<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Urinalysis Is Effective for UTIs in Younger Febrile Infants<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — For febrile infants age 60 days and younger, urinalysis is highly sensitive and specific for diagnosing urinary tract infections (UTIs), according to a study published online Jan. 16 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Cognitive Behavioral Therapy Cost-Effective in Depressed Teens<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — For adolescents with depression who declined or quickly stopped using antidepressants, a brief cognitive behavioral therapy (CBT) program is cost-effective, according to a study published online Jan. 19 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Reminder, Recall Systems Improve Immunization Uptake<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — Patient reminder and recall systems seem to be effective for improving receipt of immunizations, according to a review published online Jan. 18 in the Cochrane Library<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Risk of Psychotic Experiences Up With Teen Cannabis Use<\/font><\/p>\n FRIDAY, Jan. 19, 2018 (HealthDay News) — The risk of psychotic experiences is increased with cannabis use during adolescence, according to a study published online Jan. 17 in JAMA Psychiatry<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Professionals Disagree About Asking Patients About Sexuality<\/font><\/p>\n THURSDAY, Jan. 18, 2018 (HealthDay News) — National Health Service (NHS) England recently recommended that professionals ask all patients their sexual orientation at every opportunity, although opinions are divided on whether this is appropriate, according to an article published online Jan. 17 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Satisfaction Higher in Providers Who E-Mail Patients<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — Providers who give patients their e-mail addresses have higher satisfaction, but this does not appear to impact patient satisfaction, according to a study published recently in the European Journal for Person Centered Healthcare<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Human Rhinovirus Commonly Detected in Febrile Infants<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — For febrile infants, human rhinovirus (HRV) is common, and detection does not alter risk of concomitant urinary tract infection or invasive bacterial infection, according to a study published online Jan. 17 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Speech Outcomes Can Be Predicted After Cochlear Implant<\/font><\/p>\n WEDNESDAY, Jan. 17, 2018 (HealthDay News) — Brain areas unaffected by auditory deprivation can predict speech outcomes after cochlear implant (CI) in children, according to a study published online Jan. 15 in the Proceedings of the National Academy of Sciences of the United States of America<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Deep Brain Stimulation Tied to Improved Symptoms in Tourette<\/font><\/p>\n TUESDAY, Jan. 16, 2018 (HealthDay News) — For patients with Tourette syndrome, deep brain stimulation (DBS) is associated with symptomatic improvement but also some important adverse events, according to a study published online Jan. 16 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Spontaneous Pharynx Perforation After Forceful or Stifled Sneeze<\/font><\/p>\n TUESDAY, Jan. 16, 2018 (HealthDay News) — Spontaneous pharyngeal perforation can occur after a forceful sneeze, according to a case report published online Jan. 15 in BMJ Case Reports<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Home Visit Program Can Help Prevent Toddler Obesity<\/font><\/p>\n TUESDAY, Jan. 16, 2018 (HealthDay News) — The “Minding the Baby” (MTB) parenting home visiting program can significantly lower rates of obesity in young children, according to a study published online Jan. 16 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Considerable Economic Burden for Asthma in United States<\/font><\/p>\n FRIDAY, Jan. 12, 2018 (HealthDay News) — Asthma places a considerable economic burden on the United States, with a total cost of $81.9 billion in 2013, according to a study published online Jan. 12 in the Annals of the American Thoracic Society<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Progress in Fighting Antibiotic Resistance Shown in CDC Map<\/font><\/p>\n THURSDAY, Jan. 11, 2018 (HealthDay News) — The U.S. Centers for Disease Control and Prevention has released new data in its Antibiotic Resistance Investment Map, which shows states’ progress in combating antibiotic resistance.<\/p>\n Press Release<\/a><\/p>\n AMA Online Tools Address Systems-Level Physician Burnout<\/font><\/p>\n THURSDAY, Jan. 11, 2018 (HealthDay News) — Tools and resources have been developed to help address physician burnout at the systems level, which may affect more than half of doctors, according to a report published by the American Medical Association (AMA).<\/p>\n More Information<\/a><\/p>\n Prenatal PPI, H2 Blocker Use Linked to Asthma Risk in Child<\/font><\/p>\n THURSDAY, Jan. 11, 2018 (HealthDay News) — Prenatal, maternal, acid-suppressive drug use is associated with an increased risk of childhood asthma, according to a review published online Jan. 11 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Acetaminophen Use in Pregnancy Linked to Language Delay<\/font><\/p>\n THURSDAY, Jan. 11, 2018 (HealthDay News) — Acetaminophen (acetyl-para-aminophenol [APAP]) use in pregnancy is associated with language delay among girls, according to a study published online Jan. 10 in European Psychiatry<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Psoriasis Is Independent Risk Factor for Comorbidity in Children<\/font><\/p>\n THURSDAY, Jan. 11, 2018 (HealthDay News) — Children with psoriasis have an increased risk of comorbidities compared to children without psoriasis, independent of obesity, according to a study published online Jan. 10 in JAMA Dermatology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Some Patients Would Choose Antibiotics for Appendicitis<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — Although most patients would choose surgical intervention for treatment of acute uncomplicated appendicitis, some would opt for antibiotics alone, according to a study published online Jan. 10 in JAMA Surgery<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Economic Impact of Physicians Quantified for 2015<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — Physicians have a large economic impact across the nation, creating an aggregate of $2.3 trillion of economic activity and supporting employment of nearly 12.6 million Americans, according to a report published by the American Medical Association.<\/p>\n More Information<\/a><\/p>\n Neurodevelopment Not Impacted by Glucocorticoids in Preemies<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — Use of inhaled glucocorticoids in extremely preterm infants for the prevention of bronchopulmonary dysplasia does not lead to a higher rate of neurodevelopmental disability at 2 years, according to a study published in the Jan. 11 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n AICDs Effective for Symptoms, Lethal Arrhythmia in Brugada<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — Implantable cardioverter-defibrillators (ICDs) are effective in young patients with symptomatic Brugada syndrome, according to a study published in the Jan. 16 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n School-Based Telemedicine Asthma Management Is Effective<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — A School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) program can improve symptoms for children with persistent asthma, according to a study published online Jan. 8 in JAMA Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Black Children at Higher Risk of Death Following Surgery<\/font><\/p>\n WEDNESDAY, Jan. 10, 2018 (HealthDay News) — Race-specific models more accurately predict risk of death after surgery for pediatric patients, according to a study published online Jan. 10 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n