Age-adjusted rate of developing BIA-ALCL 16 times higher for women with mutations versus without<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
\n<\/b><\/p>\n
WEDNESDAY, June 25, 2025 (HealthDay News) — For women with breast cancer (BC), BRCA<\/em> mutations are associated with increased risk of developing breast implant\u2013associated anaplastic large cell lymphoma (BIA-ALCL), according to a study published online June 12 in Blood Advances<\/em>.<\/p>\n Paola Ghione, M.D., from Memorial Sloan Kettering Cancer Center in New York City, and colleagues examined the risk of BIA-ALCL occurrence related to BRCA<\/em> in a large population of women with textured implants followed after BC mastectomy. The prevalence of BRCA1\/2<\/em> was compared between BC patients who did and did not develop BIA-ALCL after reconstruction with textured implants. Cox regression was used to estimate hazard ratios for developing BIA-ALCL. In addition, a case\u2013control study was conducted involving 13 cases with BIA-ALCL and 39 controls.<\/p>\n The researchers found that the age-adjusted rate of developing BIA-ALCL was 16 times higher for women with versus without BRCA<\/em> among 520 patients with BC tested for BRCA<\/em>. No associations were seen for carrying bilateral implants, chemotherapy, or radiation therapy with BIA-ALCL. A complete enumeration of Bernoulli probability was used to rule out a nonassociation of BRCA<\/em> with BIA-ALCL in the case\u2013control study.<\/p>\n “If we look at the absolute numbers [seen in this study], it’s still fairly rare, but the important thing to note is that when we look at women with this genetic predisposition, there is a big jump in the percentage with this lymphoma,” Ghione said in a statement.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n