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MONDAY, March 5, 2018 (HealthDay News) — Compared with underrepresented minorities, white individuals have significantly higher positive detection rates and lower rates of inconclusive results on cardiomyopathy genetic testing, according to a study published online Feb. 28 in JAMA Cardiology<\/i>.<\/p>\n
Latrice G. Landry, Ph.D., from the U.S. Food and Drug Administration in Silver Spring, Md., and Heidi L. Rehm, Ph.D., from Brigham and Women’s Hospital in Boston, conducted a cross-sectional analysis of the genetic panel test results for 5,729 probands with a suspected diagnosis or family history of cardiomyopathy who had been referred for testing. The results were stratified into three categories: white (79.2 percent), Asian (6.1 percent), and underrepresented minorities (14.7 percent).<\/p>\n
The researchers found that positive detection occurred in 29 percent of white individuals compared with 18.4 and 25 percent of underrepresented minorities and Asians, respectively (P < 0.001 and P = 0.12, respectively). Inconclusive results were seen in 24.6 percent of whites compared with 39.8 and 39.2 percent of underrepresented minorities and Asians, respectively (both P < 0.001).<\/p>\n
“This clear disparity warrants further study to understand the gaps in usefulness, which may derive from a lack of clinical testing and research in underrepresented minority populations, in the hopes of improving genetic testing outcomes for cardiomyopathy in nonwhite groups,” the authors write.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n