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THURSDAY, Jan. 24, 2019 (HealthDay News) — In young adults, lower gray matter volume (GMV) is seen in individuals with blood pressure (BP) >120\/80 mm Hg, according to a study published online Jan. 23 in Neurology<\/i>.<\/p>\n
H. Lina Schaare, from the International Max Planck Research School in Leipzig, Germany, and colleagues examined the correlation between BP and GMV from structural 3T T1-weighted magnetic resonance imaging of 423 healthy adults aged 19 to 40 years. Data originated from four unpublished studies; voxel-based morphometry was performed on each study separately and the results were combined in image-based meta-analyses to assess the cumulative effects.<\/p>\n
The researchers found that lower regional GMV correlated with higher peripheral BP. Comparing individuals with subhypertension (systolic BP [SBP] 120 to 129 or diastolic BP [DBP] 80 to 84 mm Hg or SBP 130 to 139 and DBP 85 to 89 mm Hg) with those with SBP <120 and DBP <80 mm Hg, lower GMV was found with higher BP. In regions including hippocampus, amygdala, thalamus, frontal, and parietal structures, there was lower BP-related GMV.<\/p>\n
“Contrary to assumptions that BP-related brain damage arises over years of manifest disease, our data suggest that subtle pressure-related GM alterations can be observed in young adults without previously diagnosed hypertension,” the authors write. “Our results highlight the importance of taking BP levels as a continuous measure into consideration, which could help initiate such early preventive measures.”<\/p>\n
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