Inverse correlation seen for arterial flow mediated dilation with smoking frequency and amount of THC ingested<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
\n<\/b><\/p>\n
TUESDAY, June 3, 2025 (HealthDay News) — Chronic cannabis smoking and tetrahydrocannabinol (THC) ingestion are associated with endothelial dysfunction, according to a study published online May 28 in JAMA Cardiology<\/em>.<\/p>\n Leila Mohammadi, M.D., Ph.D., from the University of California in San Francisco, and colleagues conducted a cross-sectional study to examine whether cannabis use is associated with vascular endothelial dysfunction among sex- and age-matched healthy adults aged 18 to 50 years. Participants were recruited into three cohorts: marijuana smokers, THC-edible users, and nonusers. Arterial flow-mediated dilation (FMD) and carotid-femoral pulse wave velocity were measured for the participants.<\/p>\n The researchers found that among 55 participants, arterial FMD was significantly lower among marijuana smokers and THC-edible users than among nonusers (mean, 6.0 and 4.6 percent, respectively, versus 10.4 percent). In endothelial cells treated with participants’ sera, vascular endothelial growth factor-stimulated nitric oxide levels were significantly lower for the marijuana smoker versus the nonuser group (mean, 1.1 versus 1.5 nmol\/L), but no effect was seen for THC-edible users versus nonusers. There was an inverse correlation seen for FMD with smoking frequency and the amount of THC ingested.<\/p>\n “This study enhances the understanding of the potential risks to vascular health linked to cannabis use and provides more evidence that cannabis use is not benign,” the authors write.<\/p>\n One author disclosed ties to Greenstone Biosciences.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n