LPA was identified as a novel single nucleotide polymorphism that is associated with increased risk for AMD<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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TUESDAY, May 27, 2025 (HealthDay News) — Low and high high-density lipoprotein (HDL) are associated with an increased risk for age-related macular degeneration (AMD), according to a study published in the June issue of Ophthalmology<\/em>.<\/p>\n Jimmy S. Chen, M.D., from the Shiley Eye Institute at the University of California San Diego in La Jolla, and colleagues conducted a cross-sectional retrospective data analysis involving 5,028 healthy participants and 2,328 patients with AMD from the All of Us<\/em> research program to examine associations between clinical and genetic-based factors related to lipoprotein metabolism and the risk for AMD.<\/p>\n The researchers found that statin use and low and high HDL were significantly associated with an increased risk for AMD in a multivariable regression analysis. Certain HDL-associated single nucleotide polymorphisms (SNPs) increased the risk for AMD in multivariate regression. LPA<\/em>, a major protein associated with lipoprotein(a), was identified as a novel SNP that is associated with an increased risk for AMD (odds ratio, 1.37).<\/p>\n “These findings highlight an exciting application of the wealth of clinical and genetic data in the All of Us<\/em> dataset to highlight novel associations with the retinal disease pathophysiology of AMD,” the authors write.<\/p>\n One author disclosed ties to Topcon, which manufactures equipment for ophthalmology and surveying.<\/p>\n