{"id":14964,"date":"2019-01-08T00:00:00","date_gmt":"2019-01-08T00:00:00","guid":{"rendered":"http:\/\/medgoo.com\/index.php\/2019\/01\/08\/racial-differences-idd-in-some-biomarkers-of-alzheimers-disease\/"},"modified":"2019-01-09T16:57:21","modified_gmt":"2019-01-09T16:57:21","slug":"racial-differences-idd-in-some-biomarkers-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2019\/01\/08\/racial-differences-idd-in-some-biomarkers-of-alzheimers-disease\/","title":{"rendered":"Racial Differences ID&#8217;d in Some Biomarkers of Alzheimer&#8217;s Disease"},"content":{"rendered":"<h3>African-Americans have lower mean CSF concentration of total tau, phosphorylated tau<sub>181<\/sub><\/h3>\n<p><b><\/b><\/p>\n<p><b><\/b><\/p>\n<p>TUESDAY, Jan. 8, 2019 (HealthDay News) &#8212; Certain molecular biomarkers for Alzheimer&#8217;s disease differ with race, according to a study published online Jan. 7 in <i>JAMA Neurology<\/i>.<\/p>\n<p>John C. Morris, M.D., from the Washington University School of Medicine in St. Louis, and colleagues enrolled 1,255 participants in longitudinal studies. Participants underwent magnetic resonance imaging of the brain and\/or positron emission tomography of the brain with Pittsburgh compound B and\/or cerebrospinal fluid (CSF) assays.<\/p>\n<p>The researchers found no racial differences in the frequency of cerebral ischemic lesions noted on results of brain magnetic resonance imaging, in mean cortical standardized uptake value ratios for Pittsburgh compound B, or for amyloid-\u03b242 concentrations in the CSF. Mean total hippocampal volumes were lower for African-American versus white participants among individuals with a reported family history of dementia (6,418.26 versus 6,990.50 mm\u00b3). Compared with whites, African-Americans had lower mean CSF concentrations of total tau (293.65 versus 443.28 pg\/mL) and lower mean concentrations of phosphorylated tau<sub>181<\/sub> (53.18 versus 70.73 pg\/mL). A significant interaction between race and <i>APOE<\/i> \u03b54 was seen for CSF total tau and phosphorylated tau<sub>181<\/sub>; racial differences were only seen for <i>APOE<\/i> \u03b54-positive participants.<\/p>\n<p>&#8220;Racial differences in Alzheimer biomarkers suggest possible race-dependent biological mechanisms that contribute to expression of disease,&#8221; the authors write.<\/p>\n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jamaneurology\/article-abstract\/2719700\" target=\"_new\">Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jamaneurology\/article-abstract\/2719697\" target=\"_new\">Editorial (subscription or payment may be required)<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2019 <a href=\"https:\/\/www.healthday.com\/\" target=\"_new\">HealthDay<\/a>. All rights reserved.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>African-Americans have lower mean CSF concentration of total tau, phosphorylated tau<sub>181<\/sub><\/p>\n","protected":false},"author":6,"featured_media":14995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-14964","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/14964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=14964"}],"version-history":[{"count":0,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/14964\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/14995"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=14964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=14964"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=14964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}