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WEDNESDAY, Jan. 2, 2019 (HealthDay News) — Canagliflozin is not associated with increased fracture risk versus glucagon-like peptide-1 (GLP-1) agonists for middle-aged patients with type 2 diabetes, according to a study published online Jan. 1 in the Annals of Internal Medicine<\/i>.<\/p>\n
Michael Fralick, M.D., from Brigham and Women’s Hospital in Boston, and colleagues estimated the risk for nonvertebral fracture among new users of canagliflozin versus a GLP-1 agonist using data from two commercial health care databases containing data on more than 70 million patients. A total of 79,964 patients with type 2 diabetes who initiated canagliflozin were propensity score-matched to 79,964 patients initiating GLP-1 agonist use (mean age, 55 years).<\/p>\n
The researchers found that the primary outcome (composite end point of humerus, forearm, pelvis, or hip fracture requiring intervention) was similar for canagliflozin and GLP-1 agonists (2.2 and 2.3 events, respectively, per 1,000 person-years), with an overall hazard ratio of 0.98 (95 percent confidence interval, 0.75 to 1.26). They observed a similar risk for pelvic, hip, humerus, radius, ulna, carpal, metacarpal, metatarsal, or ankle fracture for canagliflozin and GLP-1 agonists (14.5 and 16.1 events, respectively, per 1,000 person-years; overall hazard ratio, 0.92; 95 percent confidence interval, 0.83 to 1.02).<\/p>\n
“These results should be reassuring to patients and physicians who are considering the potential risks and benefits of canagliflozin,” the authors write.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
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