Authors say findings confirm safety of COVID-19 vaccine during pregnancy<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b>
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THURSDAY, May 15, 2025 (HealthDay News) — There is no association between COVID-19 vaccination in pregnancy and spontaneous abortion, according to a study published online May 2 in Obstetrics & Gynecology<\/em>.<\/p>\n Sangini S. Sheth, M.D., from the Yale School of Medicine in New Haven, Connecticut, and colleagues examined the association between COVID-19 vaccination and spontaneous abortion. Analysis included patients aged 16 to 49 years with singleton pregnancies, one or more prenatal visits, and continuous health plan enrollment. Those with spontaneous abortion (296; between 6 and less than 20 weeks of gestation) were matched with 592 live births between Jan. 19, 2021, and Oct. 27, 2021.<\/p>\n The researchers found that there was no association between spontaneous abortion and COVID-19 vaccination (adjusted odds ratio [aOR], 0.85; 95 percent confidence interval [CI], 0.56 to 1.30). Similarly, there was no association between spontaneous abortion and dose number versus no vaccine (one dose: aOR, 0.81; 95 percent CI, 0.39 to 1.70; two doses: aOR, 0.84; 95 percent CI, 0.51 to 1.38; vaccine manufacturer: Moderna aOR, 0.59 [95 percent CI, 0.29 to 1.19], Pfizer-BioNTech aOR, 0.97 [95 percent CI, 0.57 to 1.66]). Lastly, there was no association for vaccine exposure window of six weeks before spontaneous abortion or index date (aOR, 0.87; 95 percent CI, 0.53 to 1.44).<\/p>\n “This is a rigorously conducted study that continues to show that the COVID-19 vaccines are safe during pregnancy,” Sheth said in a statement. “For women who are early in pregnancy or those who are thinking about getting pregnant, given the risks of COVID-19 disease, they should feel encouraged to go ahead and get vaccinated if they are not already.”<\/p>\n Several authors disclosed ties to the pharmaceutical industry.<\/p>\n