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MONDAY, Dec. 31, 2018 (HealthDay News) — For average-risk patients, a negative colonoscopy result is associated with a long-term reduction in the risk for colorectal cancer and related deaths, according to a study published online Dec. 17 in JAMA Internal Medicine<\/i>.<\/p>\n
Jeffrey K. Lee, M.D., from Kaiser Permanente San Francisco, and colleagues conducted a retrospective cohort study in an integrated health care delivery organization. The authors used data from 1,251,318 average-risk screening-eligible patients aged 50 to 75 years to examine the long-term risks for colorectal cancer and colorectal cancer deaths after a negative colonoscopy result.<\/p>\n
The researchers found that participants with a negative colonoscopy result had a reduced risk for colorectal cancer and related deaths through the more than 12-year follow-up period compared with unscreened participants. With increasing years of follow-up, the reductions in risk were attenuated, but at the current guideline-recommended 10-year rescreening interval, the risks were significantly lower (hazard ratios, 0.54 and 0.12 for colorectal cancer and related deaths, respectively).<\/p>\n
“Our findings can inform guideline recommendations for rescreening and future studies to evaluate the costs and benefits of earlier [versus] later rescreening intervals,” the authors write.<\/p>\n
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