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Here are what the editors at HealthDay consider to be the most important developments in Pathology for February 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.<\/p>\n
Urinary 8-oxoGsn Promising Biomarker for Physiologic Age<\/font><\/p>\n WEDNESDAY, Feb. 28, 2018 (HealthDay News) — 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) is a promising biomarker for physiologic age, corresponding more closely with age than 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGsn), according to a study published online Feb. 27 in Frontiers in Aging Neuroscience<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Sleeve Gastrectomy Linked to Improved Glycemia in Mice<\/font><\/p>\n WEDNESDAY, Feb. 28, 2018 (HealthDay News) — Sleeve gastrectomy (SG) is associated with an improvement in glycemia, via increased insulin sensitivity, according to a study published online Feb. 23 in Diabetes<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Many Untreated CIN2 Lesions Regress Spontaneously<\/font><\/p>\n WEDNESDAY, Feb. 28, 2018 (HealthDay News) — Most untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions regress, especially among women younger than 30 years, according to a review published online Feb. 27 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n New Risk Score Assesses Stroke Risk After MI Without A-Fib<\/font><\/p>\n WEDNESDAY, Feb. 28, 2018 (HealthDay News) — A new risk score incorporates readily accessible risk factors associated with the occurrence of stroke in patients after myocardial infarction (MI) in the absence of atrial fibrillation (AF), according to a study published in the Feb. 20 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Early Studies Often Show Exaggerated Treatment Effect<\/font><\/p>\n TUESDAY, Feb. 27, 2018 (HealthDay News) — Trials to evaluate drugs or devices used to treat chronic medical conditions that are published early in the chain of evidence often show an exaggerated treatment effect compared with subsequent trials, according to research published online Feb. 21 in the Mayo Clinical Proceedings<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Women With Non-Obstructive CAD May Suffer From Myocardial Scars<\/font><\/p>\n TUESDAY, Feb. 27, 2018 (HealthDay News) — Among women with suspected ischemia and no obstructive coronary artery disease (INOCA), the prevalence of baseline late gadolinium enhancement (LGE) indicating presence of myocardial scars is 8 percent, according to a research letter published in the Feb. 20 issue of Circulation<\/i>, a Go Red For Women issue focused on women’s heart health.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Sleeve Gastrectomy Tied to Drop in GDM, Excessive Fetal Growth<\/font><\/p>\n TUESDAY, Feb. 27, 2018 (HealthDay News) — Laparoscopic sleeve gastrectomy is associated with a lower rate of gestational diabetes mellitus and excessive fetal growth, according to a study published online Feb. 5 in Obstetrics & Gynecology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Lead, Other Toxic Metals Found in E-Cigarette Vapors<\/font><\/p>\n MONDAY, Feb. 26, 2018 (HealthDay News) — Toxic metals, including lead, leak from some Electronic cigarettes (e-cigarettes) heating coils and are present in the aerosols inhaled by users, according to a study published in the February issue of Environmental Health Perspectives<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Recommendations for Optimizing Hidden Curriculum in Medicine<\/font><\/p>\n MONDAY, Feb. 26, 2018 (HealthDay News) — In a position paper published online Feb. 27 in the Annals of Internal Medicine<\/i>, the American College of Physicians (ACP) presents recommendations for optimizing clinical learning environments by fostering a positive hidden curriculum in medicine.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Factors Tied to Molecular Testing by Dermatopathologists ID’d<\/font><\/p>\n MONDAY, Feb. 26, 2018 (HealthDay News) — Among dermatopathologists, relevant instruction during residency training, primary board certification in pathology, and academic medical center affiliation are among the factors associated with more frequent utilization of molecular testing, according to a study published online Feb. 13 in the Journal of Cutaneous Pathology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Coronary Artery Dz Extent Similar in Men, Women With T1DM<\/font><\/p>\n MONDAY, Feb. 26, 2018 (HealthDay News) — For patients with type 1 diabetes, the extent of coronary artery disease (CAD) is similar in women and men admitted for coronary angiography, according to a study published online Feb. 20 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n MRI Risk Model May Cut Biopsy Use in Suspected Prostate Cancer<\/font><\/p>\n MONDAY, Feb. 26, 2018 (HealthDay News) — A risk model including magnetic resonance imaging (MRI)-derived parameters may reduce the number of unnecessary biopsies among patients with suspected prostate cancer, according to a study published online Feb. 22 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Artificial Intelligence May Help Prevent Physician Burnout<\/font><\/p>\n FRIDAY, Feb. 23, 2018 (HealthDay News) — Artificial intelligence (AI), in which computers can be trained to recognize patterns in large quantities of data, may be able to reduce physicians’ burdens, saving them time and energy, according to a report published in Medical Economics<\/i>.<\/p>\n More Information<\/a><\/p>\n Growth Rates of Small Renal Masses Highly Variable Early On<\/font><\/p>\n FRIDAY, Feb. 23, 2018 (HealthDay News) — Among patients who opt for active surveillance of small renal masses, growth rates are highly variable early on and do not reliably predict adverse outcomes, according to a study published in the March issue of The Journal of Urology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Menopausal Hormone Therapy Tied to Less Pronounced Kyphosis<\/font><\/p>\n FRIDAY, Feb. 23, 2018 (HealthDay News) — Menopausal hormone therapy (HT) use is associated with less pronounced kyphosis compared with never-use, according to a study published online Feb. 16 in Menopause<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Dermoscopic Criteria Identified for Diagnosing Melanoma in Situ<\/font><\/p>\n FRIDAY, Feb. 23, 2018 (HealthDay News) — The most frequent dermoscopic criteria for melanoma in situ (MIS) are regression, atypical network, and irregular dots and\/or globules, according to a study published online Feb. 21 in JAMA Dermatology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Younger Onset of T2DM Linked to Increased Mortality Risk<\/font><\/p>\n FRIDAY, Feb. 23, 2018 (HealthDay News) — Younger onset of type 2 diabetes is associated with increased mortality risk, mainly due to cardiovascular disease (CVD) mortality, according to a study published online Feb. 22 in Diabetologia<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n GI Surgical Site Infections Higher in Low-Income Countries<\/font><\/p>\n WEDNESDAY, Feb. 14, 2018 (HealthDay News) — The burden of surgical site infection (SSI) after gastrointestinal surgery is greater for countries with low income as classified by the U.N. Human Development Index (HDI), according to a study published online Feb. 13 in The Lancet Infectious Diseases<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Gut Microbiota May Affect Vertical Transmission of Being Overweight<\/font><\/p>\n THURSDAY, Feb. 22, 2018 (HealthDay News) — The correlation between maternal pre-pregnancy overweight and childhood overweight at ages 1 and 3 years may be mediated by birth mode and infant gut microbiota, according to a study published online Feb. 19 in JAMA Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n CDC: No Change in Percentage of Uninsured in U.S. From ’16 to ’17<\/font><\/p>\n THURSDAY, Feb. 22, 2018 (HealthDay News) — The percentage of uninsured U.S. persons of all ages did not change significantly from 2016 to the first nine months of 2017, according to a report published online Feb. 22 by the National Center for Health Statistics.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Regardless of CV Risks, Cancer History Impacts Mortality<\/font><\/p>\n THURSDAY, Feb. 22, 2018 (HealthDay News) — Cancer history has an important impact on mortality independent of cardiovascular risk factors (CVRFs), according to a study published online Feb. 12 in the Journal of Thrombosis and Haemostasis<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Odds of ARDS Up After Cardiac Surgery During Flu Season<\/font><\/p>\n WEDNESDAY, Feb. 21, 2018 (HealthDay News) — Undergoing cardiac surgery during the influenza season is associated with increased likelihood of development of acute respiratory distress syndrome (ARDS), according to a research letter published in the Feb. 21 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n In A-Fib Patients, Stroke Risk Higher for Blacks Than Whites<\/font><\/p>\n WEDNESDAY, Feb. 21, 2018 (HealthDay News) — Compared with whites, blacks are at increased risk of developing an ischemic stroke either before or after diagnosis of atrial fibrillation (AF), according to a study published online Feb. 20 in Heart Rhythm<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Obesity Linked to Improved Survival in Metastatic Melanoma<\/font><\/p>\n WEDNESDAY, Feb. 21, 2018 (HealthDay News) — For men with metastatic melanoma treated with targeted or immune therapy, obesity is associated with improved survival, according to a study published online Feb. 13 in The Lancet Oncology<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Mental Stress-Induced Myocardial Ischemia Risk Up for Women<\/font><\/p>\n WEDNESDAY, Feb. 21, 2018 (HealthDay News) — Compared with men, women have an increased risk of mental stress-induced myocardial ischemia (MSIMI) after myocardial infarction (MI), with microvascular dysfunction and peripheral vasoconstriction with mental stress implicated in MSIMI in women, according to a study published in the Feb. 20 issue of Circulation<\/i>, a Go Red For Women issue focused on women’s heart health.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Burnout Found Prevalent Among Doctors in Single Health System<\/font><\/p>\n TUESDAY, Feb. 20, 2018 (HealthDay News) — Burnout is prevalent among physicians, affecting over one-third of physicians in a single health system, and is associated with health care delivery, according to a research letter published online Feb. 19 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Mortality Risks of Exclusive Cigar, Cigarette, Pipe Use ID’d<\/font><\/p>\n TUESDAY, Feb. 20, 2018 (HealthDay News) — Exclusive current cigarette and cigar use is associated with increased risk of all-cause mortality, according to a study published online Feb. 19 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Prognostic Signatures Compared for ER-Positive Breast Cancer<\/font><\/p>\n TUESDAY, Feb. 20, 2018 (HealthDay News) — For women with node-negative early endocrine receptor (ER)-positive breast cancer, the PAM50-based Prosigna risk of recurrence (ROR), Breast Cancer Index (BCI), and EndoPredict (EPclin) provide the most prognostic information, according to a study published online Feb. 15 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Molecular Markers May ID Alzheimer’s Before Clinical Onset<\/font><\/p>\n FRIDAY, Feb. 16, 2018 (HealthDay News) — For young adults with autosomal dominant Alzheimer’s disease (AD), molecular markers can identify changes associated with the disease before clinical onset, according to a study published online Feb. 12 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Anti-Heroin Vaccine Shows Promise Against Lethal Doses<\/font><\/p>\n FRIDAY, Feb. 16, 2018 (HealthDay News) — A toll-like receptor 9 (TLR9) agonist in the presence of alum is stable over a month and elicits strong anti-heroin antibody titers and blockade of heroin-induced antinociception, according to a study published online Feb. 8 in Molecular Pharmaceutics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Influenza A(H3N2) Viruses Predominate 2017-2018 Season<\/font><\/p>\n FRIDAY, Feb. 16, 2018 (HealthDay News) — Most influenza viruses identified in the 2017 to 2018 season are influenza A, with A(H3N2) viruses predominating, according to research published in the Feb. 16 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text – Budd<\/a><\/p>\n Abstract\/Full Text – Flannery<\/a><\/p>\n Induced Pluripotent Stem Cell Vaccine Promising for Cancer<\/font><\/p>\n THURSDAY, Feb. 15, 2018 (HealthDay News) — Induced pluripotent stem cell (iPSC) vaccines prevent tumor growth in syngeneic murine cancer models in a prophylactic setting, according to a study published online Feb. 15 in Cell Stem Cell<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Ultra-Processed Food Linked to Increased Overall Cancer Risk<\/font><\/p>\n THURSDAY, Feb. 15, 2018 (HealthDay News) — Consumption of ultra-processed food is associated with increased risk of overall and breast cancer, according to a study published online Feb. 14 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Increased Premature Mortality Risk Seen for Single Fathers<\/font><\/p>\n THURSDAY, Feb. 15, 2018 (HealthDay News) — Single fathers have a significantly higher risk of mortality than single mothers or partnered fathers, according to a study published online Feb. 14 in The Lancet Public Health<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Laryngovideostroboscopy Useful for Vocal Fold Lesion Screening <\/font><\/p>\n THURSDAY, Feb. 15, 2018 (HealthDay News) — Laryngovideostroboscopy (LVS) is effective for screening each patient with persistent dysphonia for vocal fold lesions, according to a study published online Jan. 10 in Head & Neck<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Poor Outcomes With Systolic BP Below 120 mm Hg in HFpEF<\/font><\/p>\n WEDNESDAY, Feb. 14, 2018 (HealthDay News) — For hospitalized patients with heart failure with preserved ejection fraction (HFpEF), poor outcomes are seen in association with a systolic blood pressure (SBP) level below 120 mm Hg, according to a study published online Feb. 14 in JAMA Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n New Model Stratifies Patients With Long Bone Metastases<\/font><\/p>\n WEDNESDAY, Feb. 14, 2018 (HealthDay News) — A model with four categories has been developed to stratify patients with symptomatic long bone metastases (LBM) based on their expected survival, according to an article published online Feb. 7 in the Journal of Bone & Joint Surgery<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n In Alzheimer’s, BACE1 Inhibition May Reverse Amyloid Deposition<\/font><\/p>\n WEDNESDAY, Feb. 14, 2018 (HealthDay News) — Sustained and increasing BACE1 inhibition can reverse amyloid deposition in a mouse model of Alzheimer’s disease (AD), according to a study published online Feb. 14 in the Journal of Experimental Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Low Dose-Rate Far-UVC Light Can Inactivate Influenza Virus<\/font><\/p>\n WEDNESDAY, Feb. 14, 2018 (HealthDay News) — Very low-dose 222-nm UVC ultraviolet light can inactivate more than 95 percent of aerosolized H1N1 influenza virus, according to a study published online Feb. 9 in Scientific Reports<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Higher Biopsy Rates for Women Undergoing Screening Breast MRI<\/font><\/p>\n WEDNESDAY, Feb. 14, 2018 (HealthDay News) — Women undergoing screening breast magnetic resonance imaging (MRI) have higher biopsy rates and significantly lower cancer yield findings compared with screening mammography alone, regardless of personal history of breast cancer (PHBC), according to a study published online Feb. 12 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Genetics Should Inform Care in Noncompaction Cardiomyopathy<\/font><\/p>\n WEDNESDAY, Feb. 14, 2018 (HealthDay News) — Genetic stratification should play a role in clinical care of patients with noncompaction cardiomyopathy (NCCM), according to a study published in the Feb. 20 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Mean Depth of Ultrasonographic Penetration Greater in Autism<\/font><\/p>\n WEDNESDAY, Feb. 14, 2018 (HealthDay News) — Children with autism spectrum disorder (ASD) have a significantly greater mean depth of ultrasonographic penetration, according to a study published online Feb. 12 in JAMA Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Lipoproteins, Lipids Have Similar Ties to MI, Ischemic Stroke<\/font><\/p>\n TUESDAY, Feb. 13, 2018 (HealthDay News) — Lipoproteins and lipids are similarly associated with risk of myocardial infarction (MI) and ischemic stroke (IS) but not intracerebral hemorrhage (ICH), according to a study published in the Feb. 13 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Perfluoroalkyl Substances Linked to Greater Weight Regain<\/font><\/p>\n TUESDAY, Feb. 13, 2018 (HealthDay News) — Higher concentrations of perfluoroalkyl substances (PFASs) are associated with greater weight regain in a diet-induced weight-loss setting, according to a study published online Feb. 13 in PLOS Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Four Best Practices Outlined to Prevent Health Care Cyberattacks<\/font><\/p>\n TUESDAY, Feb. 13, 2018 (HealthDay News) — Four best practices outlined that can help prevent health care cyberattacks, which increased from 2016 to 2017, according to a report published in Managed Healthcare Executive<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n USPSTF Recommends Against Ovarian Cancer Screening<\/font><\/p>\n TUESDAY, Feb. 13, 2018 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) recommends against screening for ovarian cancer in asymptomatic women. These findings form the basis of a final recommendation statement published in the Feb. 13 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Evidence Report<\/a><\/p>\n Final Recommendation Statement<\/a><\/p>\n Editorial<\/a><\/p>\n Losartan May Improve Endothelial Function in Marfan Syndrome<\/font><\/p>\n TUESDAY, Feb. 13, 2018 (HealthDay News) — The therapeutic significance of losartan in Marfan syndrome (MFS) may lie in its ability to activate protective endothelial function, not in its angiotensin II (AngII) receptor type 1 (ATR1) inhibition, according to a study published online Feb. 9 in the American Journal of Pathology<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Opioid Use Linked to Risk of Invasive Pneumococcal Disease<\/font><\/p>\n MONDAY, Feb. 12, 2018 (HealthDay News) — Opioid use is associated with elevated risk of invasive pneumococcal disease (IPD), especially for long-acting, high-potency, and high-dose opioids, according to a study published online Feb. 13 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Limited Evidence for Effect of Cranial Electrical Stimulation<\/font><\/p>\n MONDAY, Feb. 12, 2018 (HealthDay News) — Evidence for the effectiveness of cranial electrical stimulation (CES) is sparse, according to a review published online Feb. 13 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n