Efanesoctocog alfa needs to be priced at <53 and <59 percent of current price for conventional and distributional cost-effectiveness<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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MONDAY, April 28, 2025 (HealthDay News) — For U.S. patients with severe hemophilia A, prophylaxis with efanesoctocog alfa is neither conventionally nor distributionally cost-effective, according to a study published online April 22 in the Annals of Internal Medicine<\/em>.<\/p>\n Satoko Ito, M.D., Ph.D., from the Yale School of Medicine in New Haven, Connecticut, and colleagues examined the conventional and distributional cost-effectiveness of prophylaxis with efanesoctocog alfa versus standard-care factor VIII (standard and extended half-life) in the United States using a Markov model.<\/p>\n The researchers found that efanesoctocog alfa and standard-care factor VIII accrued 19.7 and 14.6 discounted lifetime quality-adjusted life years (QALYs) at costs of $22.1 and $11.2 million, respectively; the incremental cost-effectiveness ratio per QALY was $2.13 million. The distributional cost-effectiveness analysis-derived threshold equity weight was 6.9, which exceeded U.S. equity standards that are commonly used. Across all scenario analyses, the results were consistent. In a sensitivity analysis, the conclusion could only be changed by the price of efanesoctocog alfa. For conventional and distributional cost-effectiveness, efanesoctocog alfa needs to be priced at less than 53 and less than 59 percent of its current price, respectively. In 100 percent of 10,000 probabilistic iterations, standard-care factor VIII was favored.<\/p>\n “Alternative pricing mechanisms, longer-term clinical follow-up data, and studies across additional jurisdictions where efanesoctocog alfa is approved will be critical to understanding the value of this therapy in the context of existing treatment options in the hemophilia A arena,” the authors write.<\/p>\n Several authors disclosed ties to relevant organizations.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n