Authors say these factors can inform steps individuals can take to lower their risks for age-related brain diseases<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b>
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THURSDAY, April 10, 2025 (HealthDay News) — Seventeen modifiable risk factors are shared by stroke, dementia, and late-life depression, according to a review published online April 3 in the Journal of Neurology, Neurosurgery & Psychiatry<\/em>.<\/p>\n Jasper Senff, M.D., from Massachusetts General Hospital in Boston, and colleagues conducted a systematic literature review to identify overlapping risk factors for stroke, dementia, and late-life depression and calculate their relative impact on a composite outcome.<\/p>\n Using data from 59 selected meta-analyses, the researchers identified disability-adjusted life year (DALY)-weighted risk factors for the composite outcome that included alcohol (normalized \u03b2-coefficient highest category, \u221234), blood pressure (130), body mass index (70), fasting plasma glucose (94), total cholesterol (22), leisure-time cognitive activity (\u221291), depressive symptoms (57), diet (51), hearing loss (60), kidney function (101), pain (42), physical activity (\u221256), purpose in life (\u221250), sleep (76), smoking (91), social engagement (53), and stress (55).<\/p>\n “Dementia, stroke, and late-life depression are connected and intertwined, so if you develop one of them, there’s a substantial chance you may develop another one in the future,” Senff said in a statement. “And because they share these overlapping risk factors, preventive efforts could lead to a reduction in the incidence of more than one of these diseases, which provides an opportunity to simultaneously reduce the burden of age-related brain diseases.”<\/p>\n Several authors disclosed ties to the pharmaceutical, medical device, and biotechnology industries.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n