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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for October 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.<\/p>\n
Opioid Use Often Persists in Workers’ Compensation Claimants<\/font><\/p>\n WEDNESDAY, Oct. 31, 2018 (HealthDay News) — Many patients in a workers’ compensation cohort have persistent opioid use, according to a study published online Oct. 26 in JAMA Network Open<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk<\/font><\/p>\n WEDNESDAY, Oct. 31, 2018 (HealthDay News) — Prescription of antibiotics and acid-suppressing medications in early childhood is associated with an increased risk for obesity, according to a study published online Oct. 30 in Gut<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Link Between Statins, Non-CVD Outcomes Lacks Evidence<\/font><\/p>\n WEDNESDAY, Oct. 31, 2018 (HealthDay News) — There is a lack of convincing evidence for an association between statin use and non-cardiovascular disease (CVD) outcomes, according to a review published in the Oct. 16 issue of the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Angiotensin-Converting Enzyme Inhibitors May Up Lung CA Risk<\/font><\/p>\n TUESDAY, Oct. 30, 2018 (HealthDay News) — The use of angiotensin-converting enzyme inhibitors (ACEIs) is associated with an increased risk for lung cancer compared with angiotensin receptor blockers, according to a study published online Oct. 24 in the BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Pilot Studies May Shed Light on How to Treat Lymphedema<\/font><\/p>\n TUESDAY, Oct. 30, 2018 (HealthDay News) — Treatment with ketoprofen may improve the skin biology in lymphedema, with improvements noted in histopathology and skin thickness, according to a study published online Oct. 18 in JCI Insight<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Health Officers Express Concerns About Vaccine Exemptions<\/font><\/p>\n MONDAY, Oct. 29, 2018 (HealthDay News) — After the passage of Senate Bill 277 (SB277) in California, which eliminated nonmedical vaccine exemptions for school entry, health officers and immunization staff reported concerns including an increase in medical exemptions, according to a study published online Oct. 29 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n In Complicated UTI, Cefiderocol Noninferior to Imipenem-Cilastin<\/font><\/p>\n MONDAY, Oct. 29, 2018 (HealthDay News) — For complicated urinary tract infections caused by multidrug-resistant Gram-negative uropathogens, the siderophore cephalosporin cefiderocol is non-inferior to imipenem-cilastatin, according to a study published online Oct. 25 in The Lancet Infectious Diseases<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Durvalumab Extends Survival in Stage III Non-Small Cell Lung CA<\/font><\/p>\n MONDAY, Oct. 29, 2018 (HealthDay News) — Durvalumab results in significantly longer overall survival than placebo among patients with stage III, unresectable non-small cell lung cancer who did not have disease progression after concurrent chemoradiotherapy, according to a study published Sept. 25 in the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Trump Administration Announces Plan to Cut Drug Prices<\/font><\/p>\n FRIDAY, Oct. 26, 2018 (HealthDay News) — In an effort to cut high drug costs, the prices paid by Medicare for certain prescription drugs would be based on those in other advanced industrial nations, according to a proposal announced Oct. 25 by the Trump administration.<\/p>\n HHS Study<\/a><\/p>\n New York Times<\/i> Article<\/a><\/p>\n Prior-Season Vaccination Does Not Curb Flu Shot Effectiveness<\/font><\/p>\n FRIDAY, Oct. 26, 2018 (HealthDay News) — Prior-season vaccination is not associated with reduced vaccine effectiveness (VE) among children aged 2 to 17 years, according to a study published online Oct. 26 in JAMA Network Open<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Giving Patients Treatment Choice Improves PTSD Outcomes<\/font><\/p>\n FRIDAY, Oct. 26, 2018 (HealthDay News) — Giving patients with post-traumatic stress disorder (PTSD) their preferred treatment improves adherence and symptoms, according to a study published online Oct. 19 in The American Journal of Psychiatry<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n High-Coverage Rollout of PReP Tied to Drop in HIV Diagnoses<\/font><\/p>\n FRIDAY, Oct. 26, 2018 (HealthDay News) — A rapid, targeted, high-coverage rollout of HIV pre-exposure prophylaxis (PrEP) is associated with a decrease in HIV diagnoses among high-risk men who have sex with men (MSM), according to a study published online Oct. 17 in The Lancet<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Neither Haloperidol, Ziprasidone Shortens Delirium in ICU<\/font><\/p>\n THURSDAY, Oct. 25, 2018 (HealthDay News) — For patients with acute respiratory failure or shock and hypoactive or hyperactive delirium in the intensive care unit, neither haloperidol nor ziprasidone alters the duration of delirium compared with placebo, according to a study published online Oct. 22 in the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Bill to Fight U.S. Opioid Crisis Signed Into Law<\/font><\/p>\n THURSDAY, Oct. 25, 2018 (HealthDay News) — A bipartisan bill meant to combat the United States’ opioid abuse epidemic was signed into law Oct. 24 by President Donald Trump.<\/p>\n More Information<\/a><\/p>\n Open Surgery for Early Lung CA Tied to Long-Term Opioid Use<\/font><\/p>\n THURSDAY, Oct. 25, 2018 (HealthDay News) — Surgical invasiveness might play a role in the odds of becoming a long-term opioid user after early-stage lung cancer surgery, according to a research letter published online Sept. 24 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n FDA Approves First New Influenza Drug in 20 Years<\/font><\/p>\n WEDNESDAY, Oct. 24, 2018 (HealthDay News) — For the first time in nearly two decades, the U.S. Food and Drug Administration has approved a new type of antiviral influenza drug.<\/p>\n More Information<\/a><\/p>\n Almost One in 10 Treated in Hospital for Non-Fatal Injury<\/font><\/p>\n WEDNESDAY, Oct. 24, 2018 (HealthDay News) — In 2013, 9.8 per 100 people were treated in the hospital for a non-fatal injury, with costs estimated at $1.853 trillion, according to a study published online Oct. 8 in Injury Epidemiology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Algorithm-Defined Tx Duration Non-Inferior in Staph Bacteremia<\/font><\/p>\n WEDNESDAY, Oct. 24, 2018 (HealthDay News) — For patients with staphylococcal bacteremia, an algorithm that defines treatment duration results in a non-inferior rate of clinical success compared with usual care, according to a study published in the Sept. 25 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n AGA Issues Guidelines for Opioid-Induced Constipation<\/font><\/p>\n WEDNESDAY, Oct. 24, 2018 (HealthDay News) — Recommendations for medical management of opioid-induced constipation include laxatives as first-line agents, according to a guideline from the American Gastroenterological Association (AGA) published online Oct. 17 in Gastroenterology<\/i>.<\/p>\n Abstract\/Full Text – Guideline (subscription or payment may be required)<\/a><\/p>\n Abstract\/Full Text – Technical Review (subscription or payment may be required)<\/a><\/p>\n Most Supplements Contain Prohibited Stimulants<\/font><\/p>\n WEDNESDAY, Oct. 24, 2018 (HealthDay News) — Many supplements contain one or more stimulants that have been the subject of U.S. Food and Drug Administration-issued public notices, according to a research letter published online Oct. 22 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editor’s Note (subscription or payment may be required)<\/a><\/p>\n High-Dose Flu Vaccine May Cut Hospitalization in Dialysis Patients<\/font><\/p>\n WEDNESDAY, Oct. 23, 2018 (HealthDay News) — Receipt of the high-dose influenza vaccine in 2016 to 2017 was associated with lower rates of hospitalization among dialysis patients, according to a study published online Oct. 23 in the Clinical Journal of the American Society of Nephrology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n White House Unveils New Insurance Option for Small Firms<\/font><\/p>\n TUESDAY, Oct. 23, 2018 (HealthDay News) — A plan to allow small businesses to use tax-free accounts to provide health coverage for employees was announced today by the Trump administration.<\/p>\n AP News<\/i> Article<\/a><\/p>\n More Information<\/a><\/p>\n A-Fib Patients With Cancer Less Likely to See Cardiologist<\/font><\/p>\n TUESDAY, Oct. 23, 2018 (HealthDay News) — Atrial fibrillation (AF) patients with cancer are less likely to see a cardiologist and fill prescriptions for anticoagulants, according to a study published in the Oct. 16 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Intensive SBP Tx Cuts Kidney Damage Biomarkers in Incident CKD<\/font><\/p>\n TUESDAY, Oct. 23, 2018 (HealthDay News) — Patients with incident chronic kidney disease (CKD) in the setting of intensive systolic blood pressure (SBP) treatment have decreases rather than increases in kidney damage biomarkers, according to a study published online Oct. 23 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n High Uptake, Acceptability of Rapid Fentanyl Test Strips<\/font><\/p>\n MONDAY, Oct. 22, 2018 (HealthDay News) — Young adults who report injecting drugs or using heroin, cocaine, or illicitly obtained prescription pills report high uptake and acceptability of fentanyl test strips to detect illicitly manufactured fentanyl, according to a study published online Oct. 18 in the International Journal of Drug Policy<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Variability in Geographic Availability of New Antibiotics<\/font><\/p>\n FRIDAY, Oct. 19, 2018 (HealthDay News) — There is considerable variability in the geographic availability of antibiotics, according to a study published online Oct. 16 in PLOS ONE<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n CDC: Vaccination Rates More Than 95 Percent for Kindergartners<\/font><\/p>\n FRIDAY, Oct. 19, 2018 (HealthDay News) — Overall vaccination coverage is high among the nation’s kindergarten students, according to research published in the Oct. 12 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Triple Combo Regimens May Address Cause of Cystic Fibrosis<\/font><\/p>\n FRIDAY, Oct. 19, 2018 (HealthDay News) — Triple therapy with VX-659 or VX-445 combined with tezacaftor-ivacaftor shows promise for the treatment of adult patients with cystic fibrosis who have mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), according to two studies published online Oct. 18 in the New England Journal of Medicine<\/i>. The studies were published to coincide with a presentation at the annual North American Cystic Fibrosis Conference, held from Oct. 18 to 20 in Denver.<\/p>\n Abstract\/Full Text – Davies<\/a><\/p>\n Abstract\/Full Text – Keating<\/a><\/p>\n Editorial<\/a><\/p>\n More Information<\/a><\/p>\n 2014 to 2016 Saw 470 Percent Increase in HIV PrEP Use in U.S.<\/font><\/p>\n FRIDAY, Oct. 19, 2018 (HealthDay News) — From 2014 to 2016 there was an increase in the annual number of HIV preexposure prophylaxis (PrEP) users in the United States, although only about 7 percent of those with indications for PrEP were prescribed PrEP in 2016, according to research published in the Oct. 18 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Aspirin, Anticoagulants Similarly Prevent VTE After TKA<\/font><\/p>\n FRIDAY, Oct. 19, 2018 (HealthDay News) — Among patients undergoing total knee arthroplasty (TKA), aspirin alone may provide protection against postoperative venous thromboembolism (VTE) that is similar to that of other anticoagulants, according to a study published online Oct. 17 in JAMA Surgery<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Sharp Drop in U.S. Life Expectancy Rankings by 2040<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — The United States will have the largest drop in life expectancy rankings of all high-income countries by 2040, a new study says.<\/p>\n CNN<\/i> Article<\/a><\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n WHO: Congo Ebola Outbreak Not a Global Emergency<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — The latest Ebola outbreak in Congo is not yet severe enough to be declared a global emergency, the World Health Organization decided after a meeting of experts yesterday.<\/p>\n AP News<\/i> Article<\/a><\/p>\n More Information<\/a><\/p>\n HPV Vaccination Not Tied to Risky Sexual Behavior in Teen Girls<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — Implementation of a school-based human papillomavirus (HPV) vaccination program in Canada did not lead to an increase in sexual risk-taking behaviors among adolescent girls, according to a study published in the Oct. 15 issue of CMAJ<\/i>, the journal of the Canadian Medical Association.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Procurement Requirements Drive Interoperability in Health Care IT<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — Interoperability of health care information technology (IT) must be improved to facilitate creation of a fully integrated health care system that can improve health and health care at lower cost, according to a report published by the National Academy of Medicine.<\/p>\n More Information<\/a><\/p>\n CDC: Many Pregnant Women Not Receiving Immunizations<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — Many pregnant women are not getting recommended vaccinations, with less than half of those pregnant during the peak influenza vaccination period in 2017 to 2018 reporting being vaccinated before or during their pregnancy, according to research published in the Sept. 28 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Limited Evidence for OTC Preps to Treat Nasal Symptoms of Colds<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — Limited evidence is available for over-the-counter (OTC) treatments for nasal symptoms of the common cold, according to a report published online Oct. 10 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Giving Flu Shots in Pharmacies Could Up Vaccination Coverage<\/font><\/p>\n WEDNESDAY, Oct. 16, 2018 (HealthDay News) — Administering influenza vaccines through pharmacies in addition to traditional locations can increase vaccination coverage in the event of an epidemic, according to a study published online Oct. 16 in Vaccine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Gabapentin Beats Pregabalin for Chronic Sciatica<\/font><\/p>\n WEDNESDAY, Oct. 17, 2018 (HealthDay News) — For patients with chronic sciatica (CS), gabapentin (GBP) is superior to pregabalin (PGB), with fewer and less severe adverse events (AEs), according to a study published online Oct. 15 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Well-Being of Young Adults on Kidney Replacement Tx Studied<\/font><\/p>\n WEDNESDAY, Oct. 17, 2018 (HealthDay News) — For young adults receiving kidney replacement therapy (KRT), well-being and medication adherence are associated with psychological morbidity, according to a study published online Oct. 16 in the Clinical Journal of the American Society of Nephrology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial 1<\/a><\/p>\n Editorial 2<\/a><\/p>\n Long-Term Benzodiazepines Do Not Up Mortality in COPD, PTSD<\/font><\/p>\n WEDNESDAY, Oct. 17, 2018 (HealthDay News) — For patients with chronic obstructive pulmonary disease (COPD) and comorbid posttraumatic stress disorder (PTSD), long-term benzodiazepine use is not associated with mortality, but there is an association for short-term benzodiazepine use, according to a study published online Oct. 12 in the Annals of the American Thoracic Society<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Dose Range of IV Ketamine for Adjunct Tx of Depression Tested<\/font><\/p>\n WEDNESDAY, Oct. 17, 2018 (HealthDay News) — Two subanesthetic dosages of ketamine appear to provide significant symptom relief to patients with treatment-resistant depression (TRD), according to a study published online Oct. 3 in Molecular Psychiatry<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Seven-Day Metronidazole Better for Trichomoniasis Tx in Women<\/font><\/p>\n WEDNESDAY, Oct. 17, 2018 (HealthDay News) — A seven-day dose of metronidazole is associated with a reduced likelihood of being Trichomonas vaginalis<\/i>-positive at test-of-cure compared with single-dose treatment, according to a study published online Oct. 5 in The Lancet Infectious Diseases<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n CHF in Pregnancy Up for Cancer Survivors With Cardiac Toxicity<\/font><\/p>\n TUESDAY, Oct. 16, 2018 (HealthDay News) — The incidence of congestive heart failure (CHF) during pregnancy is 31 percent among women with a history of cardiotoxicity associated with cancer treatment, according to a study published in the Oct. 23 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Clinical Trials Support Efficacy of Tretinoin Lotion for Tx of Acne<\/font><\/p>\n TUESDAY, Oct. 15, 2018 (HealthDay News) — Tretinoin 0.05 percent lotion (ALTRENO Lotion) provides statistically significant improvement in patients with moderate-to-severe acne compared with placebo, according to two phase 3 studies published in the October issue of the Journal of Drugs in Dermatology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Gastric Banding, Metformin Similar for Improving Glycemia<\/font><\/p>\n TUESDAY, Oct. 16, 2018 (HealthDay News) — In adults with moderate obesity and either impaired glucose tolerance (IGT) or recently diagnosed mild type 2 diabetes (T2D), gastric banding and metformin are similarly effective for slowing disease progression over a two-year period, according to a study published online Oct. 3 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n \u03b2-Blockers in 1st Trimester Do Not Up Congenital Malformations<\/font><\/p>\n MONDAY, Oct. 15, 2018 (HealthDay News) — Maternal use of \u03b2-blockers in the first trimester of pregnancy is not associated with a large increase in the risk for overall or cardiac congenital malformations, according to a study published online Oct. 16 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Number of Children Not Receiving Vaccines Slightly Increased<\/font><\/p>\n MONDAY, Oct. 15, 2018 (HealthDay News) — Overall, vaccine coverage for children aged 19 to 35 months remained high and stable from 2013 to 2017; however, a small, but growing number of children received no vaccinations, according to research published in the Oct. 12 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Without Medicaid Expansion, Poor Patients Forgo Medical Care<\/font><\/p>\n MONDAY, Oct. 15, 2018 (HealthDay News) — Doing without medical care is much more common among low-income residents of states that have not expanded Medicaid than among low-income people in other states, according to a Government Accountability Office report.<\/p>\n AP News<\/i> Article<\/a><\/p>\n Active Pharmaceuticals ID’d in >700 Dietary Supplements <\/font><\/p>\n MONDAY, Oct. 15, 2018 (HealthDay News) — Dietary supplements often include active pharmaceuticals, even after warnings from the U.S. Food and Drug Administration, according to a study published online Oct. 12 in JAMA Network Open<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Cannabinoids Mildly Effective for Treating MS Symptoms in Adults<\/font><\/p>\n MONDAY, Oct. 15, 2018 (HealthDay News) — Cannabinoids may be mildly effective at treating spasticity, pain, and bladder dysfunction in adults with multiple sclerosis (MS), according to a review published online Oct. 12 in JAMA Network Open<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Cases Show Periodic Fasting May Cut Medication Use in T2DM<\/font><\/p>\n MONDAY, Oct. 15, 2018 (HealthDay News) — Medically supervised, therapeutic fasting regimens can help reverse type 2 diabetes (T2D) and minimize the need for pharmacological interventions, according to a case series published online Oct. 9 in BMJ Case Reports<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n