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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for October 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.<\/p>\n
Barriers to Prostate Cancer Research in Black Men Identified<\/font><\/p>\n WEDNESDAY, Oct. 31, 2018 (HealthDay News) — A lack of understanding of terminology, health care system distrust, and a lack of prostate cancer knowledge are among the barriers to genomic testing for prostate cancer and prostate cancer research participation among black men, according to a study published in the November issue of the American Journal of Preventive Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Link Between Statins, Non-CVD Outcomes Lacks Evidence<\/font><\/p>\n WEDNESDAY, Oct. 31, 2018 (HealthDay News) — There is a lack of convincing evidence for an association between statin use and non-cardiovascular disease (CVD) outcomes, according to a review published in the Oct. 16 issue of the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Genetic Risk Score IDs Breast CA Risk in Female Child CA Survivors<\/font><\/p>\n WEDNESDAY, Oct. 31, 2018 (HealthDay News) — A polygenic risk score (PRS) can identify subsequent breast cancer risk among childhood survivors of cancer, according to a study published online Oct. 26 in Clinical Cancer Research<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Black, Low-Income Women May Not Report Barriers to Care<\/font><\/p>\n WEDNESDAY, Oct. 31, 2018 (HealthDay News) — Black women, women living in poverty, and those with higher levels of distrust are less likely to report barriers to timely screening mammography, according to a study published online Sept. 24 in Cancer<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Erectile Dysfunction Common in Childhood Cancer Survivors<\/font><\/p>\n TUESDAY, Oct. 30, 2018 (HealthDay News) — The prevalence of erectile dysfunction (ED) is 29 percent among male childhood cancer survivors (CCS), according to a research letter published online Oct. 4 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n AMA Announces Initiative to Reinvent Physician Training<\/font><\/p>\n TUESDAY, Oct. 30, 2018 (HealthDay News) — The American Medical Association (AMA) today announced a new $15 million competitive grant initiative, the “Reimagining Residency” initiative, aimed at improving residency training.<\/p>\n More Information<\/a><\/p>\n Angiotensin-Converting Enzyme Inhibitors May Up Lung CA Risk<\/font><\/p>\n TUESDAY, Oct. 30, 2018 (HealthDay News) — The use of angiotensin-converting enzyme inhibitors (ACEIs) is associated with an increased risk for lung cancer compared with angiotensin receptor blockers, according to a study published online Oct. 24 in the BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Pilot Studies May Shed Light on How to Treat Lymphedema<\/font><\/p>\n TUESDAY, Oct. 30, 2018 (HealthDay News) — Treatment with ketoprofen may improve the skin biology in lymphedema, with improvements noted in histopathology and skin thickness, according to a study published online Oct. 18 in JCI Insight<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n New Method Estimates Risk for Recurrence in Breast Cancer<\/font><\/p>\n TUESDAY, Oct. 30, 2018 (HealthDay News) — The risk for breast cancer recurrence can be extracted using disease-specific survival data, according to a study published online Oct. 18 in Cancer Epidemiology, Biomarkers & Prevention<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Many Hospitals Noncompliant With Record Request Regulations<\/font><\/p>\n MONDAY, Oct. 29, 2018 (HealthDay News) — Among top-ranked U.S. hospitals, data reveal discrepancies in information provided to patients regarding medical records release processes as well as noncompliance with state and federal regulations, according to a study published online Oct. 5 in JAMA Network Open<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Healthier Diet Tied to Lower Mortality Risk in CRC Patients<\/font><\/p>\n MONDAY, Oct. 29, 2018 (HealthDay News) — Colorectal cancer (CRC) patients who follow healthy diets before or after diagnosis have a decreased risk for mortality, according to a study published online Oct. 19 in the Journal of Clinical Oncology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Smoking Associated With Head, Neck Surgery Complications<\/font><\/p>\n MONDAY, Oct. 29, 2018 (HealthDay News) — Smoking is associated with increased rates of postoperative wound disruption and subsequent reoperation among patients undergoing free flap reconstruction of the head and neck, according to a study published online Oct. 18 in JAMA Facial Plastic Surgery<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Hypofractionated Radiation OK for Localized Prostate CA <\/font><\/p>\n MONDAY, Oct. 29, 2018 (HealthDay News) — A new clinical guideline for early-stage prostate cancer supports the use of shortened courses of radiation therapy, according to an article published in Practical Radiation Oncology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Durvalumab Extends Survival in Stage III Non-Small Cell Lung CA<\/font><\/p>\n MONDAY, Oct. 29, 2018 (HealthDay News) — Durvalumab results in significantly longer overall survival than placebo among patients with stage III, unresectable non-small cell lung cancer who did not have disease progression after concurrent chemoradiotherapy, according to a study published Sept. 25 in the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Cancer Survival Higher in Teens, Young Adults Than Other Groups<\/font><\/p>\n FRIDAY, Oct. 26, 2018 (HealthDay News) — Overall, cancer survival among adolescents and young adults (AYAs) has consistently exceeded that of other age groups except during the HIV\/AIDS epidemic, according to a study published Oct. 15 in the Journal of the National Cancer Institute<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Trump Administration Announces Plan to Cut Drug Prices<\/font><\/p>\n FRIDAY, Oct. 26, 2018 (HealthDay News) — In an effort to cut high drug costs, the prices paid by Medicare for certain prescription drugs would be based on those in other advanced industrial nations, according to a proposal announced Oct. 25 by the Trump administration.<\/p>\n HHS Study<\/a><\/p>\n New York Times<\/i> Article<\/a><\/p>\n Tobacco Use Remains Leading Modifiable Cause of Cancer<\/font><\/p>\n THURSDAY, Oct. 25, 2018 (HealthDay News) — Tobacco use remains the leading modifiable cause of cancer and should be a priority for cancer control, according to a report published online Oct. 10 in CA: A Cancer Journal for Clinicians<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n Pace of Change Has Accelerated in Alternative Payment Models<\/font><\/p>\n THURSDAY, Oct. 25, 2018 (HealthDay News) — The impact of alternative payment models (APMs) on physician practices has been described in a study published by the RAND Corp. and the American Medical Association.<\/p>\n More Information<\/a><\/p>\n Open Surgery for Early Lung CA Tied to Long-Term Opioid Use<\/font><\/p>\n THURSDAY, Oct. 25, 2018 (HealthDay News) — Surgical invasiveness might play a role in the odds of becoming a long-term opioid user after early-stage lung cancer surgery, according to a research letter published online Sept. 24 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Most Supplements Contain Prohibited Stimulants<\/font><\/p>\n WEDNESDAY, Oct. 24, 2018 (HealthDay News) — Many supplements contain one or more stimulants that have been the subject of U.S. Food and Drug Administration-issued public notices, according to a research letter published online Oct. 22 in JAMA Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editor’s Note (subscription or payment may be required)<\/a><\/p>\n Hispanics With HIV Face Higher Risk for HPV-Related Cancer<\/font><\/p>\n WEDNESDAY, Oct. 24, 2018 (HealthDay News) — HIV-infected Hispanics have an increased risk for human papillomavirus (HPV)-related cancers than Hispanics in the general population, according to a study published online Oct. 22 in Cancer<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n White House Unveils New Insurance Option for Small Firms<\/font><\/p>\n TUESDAY, Oct. 23, 2018 (HealthDay News) — A plan to allow small businesses to use tax-free accounts to provide health coverage for employees was announced today by the Trump administration.<\/p>\n AP News<\/i> Article<\/a><\/p>\n More Information<\/a><\/p>\n A-Fib Patients With Cancer Less Likely to See Cardiologist<\/font><\/p>\n TUESDAY, Oct. 23, 2018 (HealthDay News) — Atrial fibrillation (AF) patients with cancer are less likely to see a cardiologist and fill prescriptions for anticoagulants, according to a study published in the Oct. 16 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Thermal Ablation Acceptable for Early Lung Cancer<\/font><\/p>\n TUESDAY, Oct. 23, 2018 (HealthDay News) — Thermal ablation (TA) is a safe, effective treatment for stage 1 non-small cell lung cancer (NSCLC), according to a study recently published in Radiology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Diagnostic Strategy Can Rule Out PE in Pregnant Women<\/font><\/p>\n MONDAY, Oct. 22, 2018 (HealthDay News) — A diagnostic strategy based on pretest clinical probability assessment, high-sensitivity D-dimer testing, bilateral lower-limb compression ultrasonography (CUS), and computed tomography pulmonary angiography (CTPA) can safely rule out pulmonary embolism (PE) in pregnant women, according to a study published online Oct. 23 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Aspirin, Anticoagulants Similarly Prevent VTE After TKA<\/font><\/p>\n FRIDAY, Oct. 19, 2018 (HealthDay News) — Among patients undergoing total knee arthroplasty (TKA), aspirin alone may provide protection against postoperative venous thromboembolism (VTE) that is similar to that of other anticoagulants, according to a study published online Oct. 17 in JAMA Surgery<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Light Use of Topical Skin Tx Before Radiotherapy Seems Safe<\/font><\/p>\n FRIDAY, Oct. 19, 2018 (HealthDay News) — Contrary to the advice most cancer patients receive, light or moderate use of topical agents before radiation treatment does not appear to increase the radiation dose to the skin, according to a study published online Oct. 18 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Sharp Drop in U.S. Life Expectancy Rankings by 2040<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — The United States will have the largest drop in life expectancy rankings of all high-income countries by 2040, a new study says.<\/p>\n CNN<\/i> Article<\/a><\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Procurement Requirements Drive Interoperability in Health Care IT<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — Interoperability of health care information technology (IT) must be improved to facilitate creation of a fully integrated health care system that can improve health and health care at lower cost, according to a report published by the National Academy of Medicine.<\/p>\n More Information<\/a><\/p>\n Deep Learning Algorithm Can ID Mammographic Breast Density<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — A deep learning (DL) algorithm can successfully assess mammographic breast density, according to a study published online Oct. 16 in Radiology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Plasma-Based Genotyping Aids Targeted Tx of Metastatic NSCLC<\/font><\/p>\n THURSDAY, Oct. 18, 2018 (HealthDay News) — Integration of plasma next-generation sequencing (NGS) into the routine management of metastatic non-small cell lung cancer (NSCLC) results in an increase in the detection of therapeutically targetable mutations, according to a study published online Oct. 11 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Recreational Marijuana Now Legal in Canada<\/font><\/p>\n WEDNESDAY, Oct. 17, 2018 (HealthDay News) — Recreational marijuana became legal in Canada today, and while many welcome the move, others have serious concerns.<\/p>\n The New York Times<\/i> Article<\/a><\/p>\n CMAJ<\/i> Editorial<\/a><\/p>\n Lung Cancer Deaths 28% Lower in California Than Rest of U.S.<\/font><\/p>\n WEDNESDAY, Oct. 17, 2018 (HealthDay News) — Annual lung cancer mortality was 28 percent lower in California than in the rest of the United States in 2013, according to a study published online Oct. 10 in Cancer Prevention Research<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Treatment Tied to Survival Benefit in Complex Bladder Cancer<\/font><\/p>\n WEDNESDAY, Oct. 17, 2018 (HealthDay News) — Cancer treatment is associated with a clinically meaningful survival benefit in older, medically complex patients with superficial bladder cancer (SBC), according to a study published online Oct. 5 in Cancer<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Positive HPV Status Tied to Better Cervical Cancer Prognosis<\/font><\/p>\n TUESDAY, Oct. 16, 2018 (HealthDay News) — Women with high-risk human papillomavirus (hrHPV)-positive cervical tumors have a substantially better prognosis than women with hrHPV-negative tumors, according to a study published online Oct. 1 in PLOS Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n CHF in Pregnancy Up for Cancer Survivors With Cardiac Toxicity<\/font><\/p>\n TUESDAY, Oct. 16, 2018 (HealthDay News) — The incidence of congestive heart failure (CHF) during pregnancy is 31 percent among women with a history of cardiotoxicity associated with cancer treatment, according to a study published in the Oct. 23 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Without Medicaid Expansion, Poor Patients Forgo Medical Care<\/font><\/p>\n MONDAY, Oct. 15, 2018 (HealthDay News) — Doing without medical care is much more common among low-income residents of states that have not expanded Medicaid than among low-income people in other states, according to a Government Accountability Office report.<\/p>\n AP News<\/i> Article<\/a><\/p>\n In NSCLC, Longer Survival With Brigatinib Than Crizotinib<\/font><\/p>\n MONDAY, Oct. 15, 2018 (HealthDay News) — Among patients with anaplastic lymphoma kinase (ALK<\/i>)-positive non-small cell lung cancer (NSCLC) who have not previously received an ALK<\/i> inhibitor, progression-free survival is significantly longer in those who receive treatment with brigatinib versus crizotinib, according to a study published online Sept. 25 in the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Active Pharmaceuticals ID’d in >700 Dietary Supplements <\/font><\/p>\n MONDAY, Oct. 15, 2018 (HealthDay News) — Dietary supplements often include active pharmaceuticals, even after warnings from the U.S. Food and Drug Administration, according to a study published online Oct. 12 in JAMA Network Open<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Multicomponent Intervention Can Reduce Sitting Time at Work<\/font><\/p>\n FRIDAY, Oct. 12, 2018 (HealthDay News) — A multicomponent intervention (Stand More At [SMArT] Work) can reduce sitting time over the short, medium, and long terms, according to a study published online Oct. 10 in The BMJ<\/i>.<\/p>\n Abstract\/Full text<\/a><\/p>\n Editorial<\/a><\/p>\n FDA Approves New DNA-Based Test to Verify Blood Compatibility<\/font><\/p>\n FRIDAY, Oct. 12, 2018 (HealthDay News) — The U.S. Food and Drug Administration has approved the ID CORE XT DNA-based test to help doctors verify blood compatibility before a transfusion.<\/p>\n More Information<\/a><\/p>\n Ultrasound Can Predict Success of AV Fistula for Hemodialysis<\/font><\/p>\n FRIDAY, Oct. 12, 2018 (HealthDay News) — Detection of arteriovenous fistula (AVF) blood flow, diameter, and depth on ultrasound can predict AVF clinical maturation, according to a study published online Oct. 11 in the Journal of the American Society of Nephrology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Low-Dose Aspirin May Reduce Ovarian Cancer Risk<\/font><\/p>\n THURSDAY, Oct. 11, 2018 (HealthDay News) — Low-dose aspirin use is associated with a reduced risk for ovarian cancer, according to a study published online Oct. 4 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Midlife PSA Predicts Aggressive Prostate Cancer in Black Men<\/font><\/p>\n THURSDAY, Oct. 11, 2018 (HealthDay News) — Midlife levels of prostate-specific antigen (PSA) strongly predict future development of aggressive prostate cancer among black men, according to a study published online Sept. 17 in European Urology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Aetna-CVS Merger Approved<\/font><\/p>\n WEDNESDAY, Oct. 10, 2018 (HealthDay News) — A $69 billion merger between health insurer Aetna and pharmacy manager CVS Health has been approved, according to the U.S. Justice Department.<\/p>\n The New York Times<\/i> Article<\/a><\/p>\n Duvelisib Promising for Chronic Lymphocytic Leukemia, SLL<\/font><\/p>\n WEDNESDAY, Oct. 10, 2018 (HealthDay News) — For patients with relapsed or refractory (RR) chronic lymphocytic leukemia (CLL)\/small lymphocytic lymphoma (SLL), the oral, dual inhibitor of phosphoinositide 3-kinase-\u03b4 and -\u03b3, duvelisib, seems effective, according to a study published online Oct. 4 in Blood<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Long-Term Aspirin Use Linked to Reduction in Liver Cancer Risk<\/font><\/p>\n WEDNESDAY, Oct. 10, 2018 (HealthDay News) — Regular long-term aspirin use is associated with a dose-dependent reduction in the risk for hepatocellular carcinoma (HCC), according to a study published online Oct. 4 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n FDA Approves HPV Vaccine for People Through Age 45<\/font><\/p>\n TUESDAY, Oct. 9, 2018 (HealthDay News) — U.S. Food and Drug Administration approval of the Gardasil 9 human papillomavirus (HPV) vaccine has been expanded to include people ages 27 through 45, the agency said in a news release.<\/p>\n More Information<\/a><\/p>\n Weight Loss May Cut Breast CA Risk in Postmenopausal Women<\/font><\/p>\n TUESDAY, Oct. 9, 2018 (HealthDay News) — Postmenopausal women with weight loss have a reduced risk for breast cancer, according to a study published online Oct. 8 in Cancer<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Integrated Classifier Identifies Benign Lung Nodules<\/font><\/p>\n TUESDAY, Oct. 9, 2018 (HealthDay News) — An integrated plasma proteomics classifier, which integrates the relative abundance of two plasma proteins with a clinical risk prediction model, can distinguish benign from malignant lung nodules in those at low-to-intermediate risk for cancer, according to a study published in the September issue of CHEST<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Minority Residents Experience Burdens Linked to Race\/Ethnicity<\/font><\/p>\n TUESDAY, Oct. 9 2018 (HealthDay News) — Minority residents describe burdens associated with race\/ethnicity, including microaggressions and bias on a daily basis, according to a study published online Sept. 28 in JAMA Network Open<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n