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FRIDAY, Oct. 26, 2018 (HealthDay News) — Procurement biopsies from deceased donor kidneys have poor reproducibility and do not correlate well with reperfusion biopsies, according to a study published online Oct. 25 in the Clinical Journal of the American Society of Nephrology<\/i> to coincide with a presentation at ASN Kidney Week 2018, held Oct. 23 to 28 in San Diego.<\/p>\n
Dustin Carpenter, M.D., from Columbia University College of Physicians and Surgeons in New York City, and colleagues compared procurement frozen section biopsy reports with reperfusion paraffin-embedded biopsies read by trained pathologists for 270 kidneys from deceased donors. Agreement for sequential procurement biopsies performed on the same kidney was also examined (n = 116).<\/p>\n
The researchers found category agreement in 64 percent of the kidneys on which more than one procurement biopsy was performed (\u03ba = 0.14). The correlation between procurement and reperfusion biopsies was poor for all kidneys. In 64 percent of cases, biopsies were classified into the same category (optimal versus suboptimal; \u03ba = 0.25). When categorizing the percentage of glomerulosclerosis, this discrepancy was most pronounced (63 percent agreement; \u03ba = 0.15). Overall, reperfusion biopsies were more prognostic than procurement biopsies, with no significant correlation for procurement biopsies with graft failure.<\/p>\n
“Limited reliance on procurement biopsy histology will likely result in an improvement in organ utilization by reducing the discard of kidneys attributable to these findings,” said a co-author in a statement.<\/p>\n
Abstract<\/a><\/p>\n Full Text (subscription or payment may be required)<\/a><\/p>\n