After adjustment for confounding variables, no increased risk seen for GLP-1 receptor agonists versus DPP-4 inhibitors, SGLT-2 inhibitors<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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MONDAY, March 3, 2025 (HealthDay News) — Glucagon-like peptide-1 (GLP-1) receptor agonists are not associated with an increased risk for suicidality compared with dipeptidyl peptidase-4 (DPP-4) inhibitors or sodium-glucose cotransporter-2 (SGLT-2) inhibitors in adjusted analyses, according to a study published online Feb. 26 in The BMJ<\/em>.<\/p>\n Samantha B. Shapiro, from the Jewish General Hospital in Montreal, and colleagues conducted an active comparator, new user cohort study to examine whether use of GLP-1 receptor agonists is associated with an increased risk for suicidal ideation, self-harm, and suicide compared with DPP-4 inhibitor or SGLT-2 inhibitor use. The first cohort included 36,082 GLP-1 receptor agonist users and 234,028 DPP-4 inhibitor users, and the second cohort included 32,336 GLP-1 receptor agonist users and 96,212 SGLT-2 inhibitor users.<\/p>\n In crude analyses, the researchers found an increased incidence of suicidality with GLP-1 receptor agonist versus DPP-4 inhibitor use (crude incidence rates, 3.9 versus 1.8 per 1,000 person-years; hazard ratio, 2.08; 95 percent confidence interval, 1.83 to 2.36). After accounting for confounding factors, this estimate decreased to a null value (hazard ratio, 1.02; 95 percent confidence interval, 0.85 to 1.23). GLP-1 receptor agonist use was also associated with an increased risk for suicidality compared with SGLT-2 inhibitor use (crude incidence rates, 4.3 versus 2.7 per 1,000 person-years; hazard ratio, 1.60; 95 percent confidence interval, 1.37 to 1.87), but the correlation did not persist after accounting for confounding factors (hazard ratio, 0.91; 95 percent confidence interval, 0.73 to 1.12). When suicidal ideation, self-harm, and suicide were analyzed separately in both cohorts, the findings were similar.<\/p>\n “These findings should provide some reassurance with respect to the psychiatric safety of these drugs,” the authors write.<\/p>\n Several authors disclosed ties to the pharmaceutical industry.<\/p>\n