Nonmalignant gynecological diseases associated with elevated risk for composite C\/CVD<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
\n<\/b><\/p>\n
FRIDAY, Feb. 28, 2025 (HealthDay News) — Nonmalignant gynecological diseases (NMGD) are associated with cardiovascular and\/or cerebrovascular disease (C\/CVD), according to a systematic review and meta-analysis published online Feb. 24 in Heart<\/em>.<\/p>\n Giorgia Elisabeth Colombo, M.B., Ch.B., from the Ospedale Regionale di Lugano in Switzerland, and colleagues conducted a systematic literature review to examine the association between NMGD and C\/CVD. A combination of ischemic heart disease, cerebrovascular disease, heart failure, and peripheral vascular disease defined the composite C\/CVD outcome.<\/p>\n The analysis included 28 studies, with 3,271,242 participants. The researchers found that 53.3 percent of the studies had a serious\/critical risk for bias. Overall, individuals with NMGD had a significantly elevated risk for composite C\/CVD (summary relative risk [SRR], 1.28; I2<\/sup> = 65.3 percent), ischemic heart disease (SRR, 1.41; I2<\/sup> = 73.7 percent), and cerebrovascular disease (SRR, 1.33; I2<\/sup> = 91.5 percent). Those with a history of endometriosis or polycystic ovary syndrome had a greater risk for C\/CVD and its components in NMGD-specific analyses.<\/p>\n “Physicians should be aware of the potential association between NMGD and C\/CVD and use this to inform clinical practice in order to mitigate the risk of C\/CVD,” the authors write. “Our findings reinforce the need for prospective longitudinal life course research evaluating risk of C\/CVD outcomes in NMGD overall and in subgroup populations, which may catalyze primary prevention strategies.”<\/p>\n Several authors disclosed ties to the pharmaceutical industry.<\/p>\n