High-intensity interval training significantly cuts risk for rapid estimated glomerular filtration rate decline<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b>
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TUESDAY, Feb. 25, 2025 (HealthDay News) — There is a dose-response relationship between physical activity and rapid kidney function decline in older adults, according to a study published online Feb. 11 in the Journal of the American Society of Nephrology<\/em>.<\/p>\n Stein I. Hallan, M.D., Ph.D., from the Norwegian University of Science and Technology in Trondheim, and colleagues investigated the dose-response effect of physical exercise on kidney function preservation in older adults (aged 70 to 77 years). The post-hoc analysis included 1,156 participants in the Generation 100 Study, who were randomly assigned to a control (education) group (385 participants), supervised moderate-intensity continuous training (70 percent of peak heart rate) for 50 minutes twice weekly for five years (380 participants), or high-intensity interval training (90 percent of peak heart rate) for four minutes four times twice weekly for five years (391 participants). <\/p>\n The researchers found that oxygen uptake increased by 1.8, 2.3, and 3.3 mL\/kg\/min in the control, moderate-intensity, and high-intensity groups, respectively. Rapid estimated glomerular filtration rate (eGFR) decline occurred across groups (30, 28, and 23 percent, respectively). For the moderate-intensity (relative risk [RR], 0.93; 95 percent confidence interval [CI], 0.75 to 1.16) and high-intensity (RR, 0.75; 95 percent CI, 0.59 to 0.95) groups, there was a significant dose-response relationship. Participants with decreasing moderate-to-vigorous activity over time (> \u221220 minutes\/week) had a trend for rapid eGFR decline (RR, 1.30; 95 percent CI, 0.93 to 1.83), while those with increasing activity (> +20 minutes\/week) had lower risk (RR, 0.73; 95 percent CI, 0.53 to 0.99) versus stable activity, when adjusting for baseline factors.<\/p>\n “Preservation of kidney function should be recognized as one of the numerous health benefits of high-intensity exercise training,” the authors write.<\/p>\n Two authors disclosed ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n