{"id":12061,"date":"2018-10-24T00:00:00","date_gmt":"2018-10-24T00:00:00","guid":{"rendered":"http:\/\/medgoo.com\/index.php\/2018\/10\/24\/tibia-lead-levels-linked-to-risk-of-resistant-hypertension\/"},"modified":"2018-10-25T16:01:47","modified_gmt":"2018-10-25T16:01:47","slug":"tibia-lead-levels-linked-to-risk-of-resistant-hypertension","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2018\/10\/24\/tibia-lead-levels-linked-to-risk-of-resistant-hypertension\/","title":{"rendered":"Tibia Lead Levels Linked to Risk of Resistant-Hypertension"},"content":{"rendered":"<h3>Relative risk of 1.19 for resistant-HTN for each interquartile range increase in tibia lead level<\/h3>\n<p><b><\/b><\/p>\n<p><b><\/b><\/p>\n<p>WEDNESDAY, Oct. 24, 2018 (HealthDay News) &#8212; Tibia lead levels are associated with resistant-hypertension (HTN), according to a study published online Oct. 24 in the <i>Journal of the American Heart Association<\/i>.<\/p>\n<p>Alexander Zheutlin, from the University of Michigan in Ann Arbor, and colleagues examined the risk of resistant-HTN based on bone lead levels in a prospective cohort study of the Normative Aging Study. Participants had clinic data on HTN and lead, and demographics and confounding variables were also examined.<\/p>\n<p>The researchers identified 97 cases of resistant-HTN among the 475 participants (20.4 percent). The median tibia and patella lead levels were 20 and 25 \u00b5g\/g among the cases of resistant-HTN, while the levels were 20 and 27.5 \u00b5g\/g in participants without resistant-HTN. There was a significant correlation for tibia lead level with resistant-HTN (relative risk, 1.19; 95 percent confidence interval, 1.01 to 1.41; P = 0.04) per interquartile range increase in tibia lead level, while there was no association for patella lead level (relative risk, 1.1; 95 percent confidence interval, 0.92 to 1.31; P = 0.31). There was no correlation for blood lead levels with resistant-HTN (relative risk, 1.11; 95 percent confidence interval, 0.88 to 1.4; P = 0.38).<\/p>\n<p>&#8220;The cumulative effect of low-level lead may manifest through more subtle mechanisms of slow interference with biochemical systems involved in vascular contractility and volume management,&#8221; the authors write.<\/p>\n<p><a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.010014\" target=\"_new\">Abstract\/Full Text<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2018 <a href=\"https:\/\/www.healthday.com\/\" target=\"_new\">HealthDay<\/a>. All rights reserved.<\/i> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Relative risk of 1.19 for resistant-HTN for each interquartile range increase in tibia lead level<\/p>\n","protected":false},"author":6,"featured_media":12079,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-12061","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/12061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=12061"}],"version-history":[{"count":0,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/12061\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/12079"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=12061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=12061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=12061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}