Among non-Hispanic Black participants, no association was seen for total calcium intake with CRC risk<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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FRIDAY, Feb. 21, 2025 (HealthDay News) — Higher calcium intake is associated with reduced colorectal cancer (CRC) risk across tumor sites and calcium sources, according to a study published online Feb. 17 in JAMA Network Open<\/em>.<\/p>\n Semi Zouiouich, Ph.D., M.P.H., from the National Cancer Institute in Bethesda, Maryland, and colleagues examined the association between calcium intake and CRC risk in a cohort study analyzing data from the National Institutes of Health-AARP Diet and Health Study involving participants aged 50 to 71 years at baseline (October 1995 to May 1996) with self-reported good health and neither extremely high nor low caloric or calcium intake.<\/p>\n The researchers identified 10,618 first primary CRC cases during 7,339,055 person-years of follow-up among 471,396 participants who were cancer-free at baseline. Mean total calcium intake for the lowest quintile (Q1) was 401 mg\/d for women and 407 mg\/d for men; mean total intake for the highest quintile (Q5) was 2,056 mg\/d for women and 1,773 mg\/d for men. A lower risk for CRC was seen in association with higher total calcium intake (Q5 versus Q1: hazard ratio, 0.71; 95 percent confidence interval, 0.65 to 0.78; P\u2009<\u2009 0.001 for trend); results were consistent across calcium sources and tumor sites. The mean calcium intake was 382 and 1,916 mg\/d for Q1 and Q5, respectively, among non-Hispanic Black participants, with no association seen for total calcium intake with CRC risk (Q5 versus Q1: HR, 0.60; 95 percent confidence interval, 0.32 to 1.13; P\u2009=\u20090.12 for trend). No evidence of effect measure difference was seen by race and ethnicity.<\/p>\n “While calcium intake may vary by race and ethnicity, the potential for calcium to play a role in CRC prevention appeared to be consistent across racial and ethnic groups; still, research in racial and ethnic minority populations is needed,” the authors write.<\/p>\n