Elevated LDL cholesterol, total cholesterol, triglycerides linked to reduced risk for glaucoma<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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WEDNESDAY, Feb. 5, 2025 (HealthDay News) — Elevated high-density lipoprotein cholesterol (HDL-C) is associated with an increased risk for glaucoma, while elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG) are associated with a reduced risk, according to a study published online Feb. 4 in the British Journal of Ophthalmology<\/em>.<\/p>\n Yiyuan Ma, from Sun Yat-sen University in Guangzhou, China, and colleagues conducted a prospective cohort study involving 400,229 participants from the U.K. Biobank to examine the associations of HDL-C, LDL-C, TC, and TG with glaucoma.<\/p>\n The researchers found that 1.72 percent of the participants developed glaucoma during a mean follow-up of 14.44 years. Higher levels of HDL-C were associated with increased glaucoma risk (hazard ratio, 1.05 [95 percent confidence interval, 1.02 to 1.08; P = 0.001] for one standard deviation increase in HDL-C) in multivariate Cox regression, while reduced risk was seen in association with elevated levels of LDL-C, TC, and TG (hazard ratios [95 percent confidence intervals], 0.96 [0.94 to 0.99; P = 0.005], 0.97 [0.94 to 1.00; P = 0.037], and 0.96 [0.94 to 0.99; P = 0.008], respectively). An analysis of associations between the polygenic risk score of serum lipids and glaucoma showed an increased hazard ratio in association with a one-standard deviation increment of HDL-C genetic risk (hazard ratio, 1.05; 95 percent confidence interval, 1.00 to 1.11; P = 0.031). There were no significant associations seen for the polygenic risk scores of LDL-C, TC, and TG with glaucoma.<\/p>\n “HDL cholesterol has been regarded as the ‘good cholesterol’ for seven decades,” the authors write. “However, this study demonstrates that high levels of HDL cholesterol are not consistently associated with a favorable prognostic outcome.”<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n