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MONDAY, Oct. 22, 2018 (HealthDay News) — For patients with metastatic triple-negative breast cancer, atezolizumab plus nanoparticle albumin-bound (nab)-paclitaxel prolongs progression-free survival compared with placebo plus nab-paclitaxel, according to a study published online Oct. 20 in the New England Journal of Medicine<\/i>. The research was published to coincide with the annual meeting of the European Society for Medical Oncology, held from Oct. 19 to 23 in Munich.<\/p>\n
Peter Schmid, M.D., Ph.D., from the Queen Mary University of London, and colleagues randomly assigned patients with untreated metastatic triple-negative breast cancer to receive either atezolizumab plus nab-paclitaxel or placebo plus nab-paclitaxel in a 1:1 ratio (451 patients in each group). Patients continued the intervention until disease progression or an unacceptable level of toxic effects.<\/p>\n
The researchers found a median progression-free survival of 7.2 and 5.5 months with atezolizumab plus nab-paclitaxel and placebo plus nab-paclitaxel, respectively (hazard ratio [HR] for progression or death, 0.80; 95 percent confidence interval [CI], 0.69 to 0.92; P = 0.002) in the intention-to-treat analysis. The median progression-free survival was 7.5 and 5.0 months, respectively, among patients with programmed death ligand 1 (PD-L1)-positive tumors (HR, 0.62; 95 percent CI, 0.49 to 0.78; P < 0.001). Median overall survival was 21.3 and 17.6 months, respectively, in the intention-to-treat analysis (HR for death, 0.84; 95 percent CI, 0.69 to 1.02; P = 0.08) and 25.0 and 15.5 months, respectively, among patients with PD-L1-positive tumors (HR, 0.62; 95 percent CI, 0.45 to 0.86).<\/p>\n
“It remains to be determined whether these findings extend to other chemoimmunotherapy combinations,” the authors write.<\/p>\n
The trial was funded by F. Hoffmann-La Roche\/Genentech, which manufactures atezolizumab.<\/p>\n
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