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MONDAY, Oct. 22, 2018 (HealthDay News) — For individuals with obstructive sleep apnea, those with short respiratory event duration have an increased risk for mortality, according to a study published online Oct. 19 in the American Journal of Respiratory and Critical Care Medicine<\/i>.<\/p>\n
Matthew P. Butler, Ph.D., from the Oregon Institute of Occupational Health Sciences in Portland, and colleagues examined whether respiratory event duration predicts all-cause mortality in a prospective community-based cohort involving 5,712 participants with obstructive sleep apnea.<\/p>\n
The researchers found that 1,290 deaths occurred over 11 years of follow-up. Individuals with events of the shortest duration had a significant hazard ratio for all-cause mortality of 1.31 after adjustment for demographic factors, apnea-hypopnea index, smoking, and prevalent cardiometabolic disease. The correlation was seen in men and women and was strongest for moderate sleep apnea (hazard ratio, 1.59).<\/p>\n
“This result seems counter-intuitive because you might expect longer periods of not breathing to be more severe,” Butler said in a statement. “On the other hand, shorter periods of disturbed breathing indicate a low arousal threshold, which would associate with sleep fragmentation, elevated sympathetic tone, and greater risk for hypertension.”<\/p>\n
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