Transgender adults with cirrhosis have higher proportions of anxiety, depression, HIV\/AIDS<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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THURSDAY, Dec. 26, 2024 (HealthDay News) — Trans- versus cisgender adults have an increased prevalence of cirrhosis but similar five-year survival, according to a study published in the December issue of the American Journal of Gastroenterology<\/em>.<\/p>\n Hirsh Elhence, from the Keck School of Medicine at the University of Southern California in Los Angeles, and colleagues calculated the age-standardized prevalence of cirrhosis among cisgender versus transgender adults in the Optum deidentified Clinformatics Data Mart Database between 2007 and 2022. For those with diagnoses of incident cirrhosis, age-standardized incidence densities of liver-related outcomes and all-cause mortality were calculated. Using inverse probability treatment weighting, five-year survival was examined.<\/p>\n Overall, 0.07 percent of the 64,615,316 adults were transgender; 0.09 percent of the 329,251 adults with cirrhosis were transgender. The researchers found that the prevalence of cirrhosis was higher for trans- versus cisgender adults (1,285 versus 561 per 100,000). Among those with cirrhosis, trans- versus cisgender adults had higher proportions of anxiety (70.7 versus 43.2 percent), depression (66.4 versus 38.4 percent), HIV\/AIDS (8.5 versus 1.6 percent), and alcohol (57.5 versus 51.0 percent) and viral etiologies (30.5 versus 24.2 percent). Similar densities of death, decompensation, and liver transplantation were seen for trans- versus cisgender adults (12.0 versus 14.0, 15.7 versus 14.1, and 0.3 versus 0.3 per 100 person-years, respectively). Transgender and cisgender individuals were found to have similar five-year survival probabilities in an inverse probability treatment weighting survival analysis (63.4 versus 59.1 percent).<\/p>\n “Our findings suggest that transgender individuals represent a vulnerable population that require specific attention from clinicians and researchers alike,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n