Reduction seen in overall cohort and in those with BMI >30, hypertension<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
\n<\/b><\/p>\n
WEDNESDAY, Nov. 20, 2024 (HealthDay News) — Among older individuals with overweight, vitamin D supplementation coadministered with calcium reduces systolic and diastolic blood pressure (SBP and DBP), according to a study published online Nov. 12 in the Journal of the Endocrine Society<\/em>.<\/p>\n Maya Rahme, from the American University of Beirut Medical Center, and colleagues examined the effect of two doses of cholecalciferol (vitamin D3<\/sub>) supplementation coadministered with calcium on SBP and DBP. Ambulatory, older adults with overweight (221) received a calcium dose and oral vitamin D3<\/sub> at 600 or 3,750 IU\/day equivalent.<\/p>\n The researchers found a significant decrease in SBP and DBP in the overall group and in the high-dose group at six and 12 months. Trends were similar in the low-dose group but did not reach statistical significance. SBP decreased significantly in both treatment groups among individuals with body mass index (BMI) >30 kg\/m2<\/sup>, while a significant decrease in DBP was only seen in the high-dose group. In the subgroups of 143 participants with hypertension, there was a decrease in SBP and DBP at six and 12 months, independent of BMI levels and at both vitamin D levels. BMI and baseline SBP significantly predicted SBP at six and 12 months, but vitamin D treatment dose did not in multivariate linear mixed models with random effects in the overall group of participants.<\/p>\n “Our trial and critical synthesis of data from other relevant randomized controlled trials suggest a putative beneficial effect of vitamin D in older populations with inadequate vitamin D levels and hypertension,” the authors write.<\/p>\n