Longer progression-free survival seen with nivolumab + doxorubicin, vinblastine, and dacarbazine (AVD) versus brentuximab vedotin + AVD<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b>
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WEDNESDAY, Oct. 16, 2024 (HealthDay News) — For patients with stage III or IV Hodgkin lymphoma, nivolumab with doxorubicin, vinblastine, and dacarbazine (N+AVD) yields longer progression-free survival (PFS) than brentuximab vedotin with doxorubicin, vinblastine, and dacarbazine (BV+AVD), according to a study published online Oct. 16 in the New England Journal of Medicine<\/em>.<\/p>\n Alex F. Herrera, M.D., from the City of Hope Comprehensive Cancer Center in Duarte, California, and colleagues conducted a phase 3, multicenter, randomized trial involving patients at least 12 years of age with stage III or IV newly diagnosed Hodgkin lymphoma. A total of 994 patients were randomly assigned to BV+AVD or N+AVD; 970 were included in the intention-to-treat population for an efficacy analysis.<\/p>\n The researchers found that the threshold for efficacy was crossed at the second planned interim analysis, with a median follow-up of 12.1 months, indicating that PFS was significantly improved with N+AVD versus BV+AVD (hazard ratio for progression or death, 0.48). The analysis was repeated with longer follow-up, and the two-year PFS was 92 and 83 percent with N+AVD and BV+AVD, respectively, with a median follow-up of 2.1 years (hazard ratio for disease progression or death, 0.45). Immune-related adverse events occurred rarely with nivolumab; more treatment discontinuation was seen with BV.<\/p>\n “On the basis of the clinically meaningful improvement in progression-free survival and excellent side-effect profile of N+AVD, the opportunity to avoid potentially toxic consolidative radiation therapy, and the decreased drug-acquisition and supportive-care costs, N+AVD should be a strong candidate for primary treatment in adolescent and adult patients with stage III or IV Hodgkin lymphoma,” the authors write.<\/p>\n Bristol Myers Squibb and SeaGen provided drugs used in the trial.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n