17.4 percent in GLP-1 RA group undergoing esophagogastroduodenoscopies had food retention versus none in the control group<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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FRIDAY, Oct. 4, 2024 (HealthDay News) — Use of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) is associated with the risk for retained gastric contents and inadequate bowel preparation during endoscopic procedures, according to a research letter published online Oct. 1 in JAMA Network Open<\/em>.<\/p>\n Jason Nasser, M.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues examined the potential associations between GLP-1 RA use and risks for gastric food retention and periprocedural aspiration during esophagogastroduodenoscopies (EGDs), when EGD was combined with colonoscopy, and in colonoscopy alone in a retrospective, single-center cross-sectional study. Individuals taking GLP-1 RAs at the time of endoscopy were matched for age, body mass index subgroup, sex, and procedure with individuals in a control group (70 and 139 individuals, respectively).<\/p>\n Overall, 33 percent of the cohort underwent EGD, 33 percent underwent colonoscopy, and 34 percent underwent both. The researchers found that four of 23 individuals (17.4 percent) in the GLP-1 RA group undergoing EGD alone and none of 46 in the control group had food retention (odds ratio, 21.5). In combined EGD-colonoscopies, there was no food retention observed. Inadequate bowel preparation was more common in the GLP-1 RA group than the control group among individuals undergoing colonoscopy or combined EGD-colonoscopies (21.3 versus 6.5 percent; odds ratio, 3.9). There were no aspiration events, respiratory distress, or aspiration pneumonia visits.<\/p>\n “Contrary to previous reports, our study identified a clear association between GLP-1 RA use and unsatisfactory bowel preparation, which carries significant risks for missed lesions, patient dissatisfaction, and procedure cancellation, with wasted resources,” the authors write.<\/p>\n