After adjustment for baseline cardiovascular risk, pulmonary vein volume receiving 5 Gy linked to atrial fibrillation<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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TUESDAY, Aug. 27, 2024 (HealthDay News) — For patients with locally advanced non-small cell lung cancer, radiotherapy dose to discrete cardiac substructures is associated with pathophysiologically distinct arrhythmia classes, according to a study published online in the August issue of JACC: CardioOncology<\/em>.<\/p>\n Katelyn M. Atkins, M.D., Ph.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues conducted a retrospective analysis of 748 patients with locally advanced non-small cell lung cancer treated with radiotherapy to examine the association of distinct arrhythmia classes with cardiac substructure radiotherapy dose.<\/p>\n Of the participants, 128 (17.1 percent) experienced at least one grade \u00e2\u0089\u00a53 arrhythmia, with a median of 2.0 years to first arrhythmia. The researchers found that the two-year cumulative incidences were 8.0 percent for atrial fibrillation (AF), 2.7 percent for atrial flutter, 1.8 percent for non-AF and non-atrial flutter supraventricular tachyarrhythmia, 1.4 percent for bradyarrhythmia, and 1.1 percent for ventricular tachyarrhythmia or asystole. Pulmonary vein (PV) volume receiving 5 Gy was associated with AF after adjustment for baseline cardiovascular risk; left circumflex coronary artery volume receiving 35 Gy was associated with atrial flutter; PV volume receiving 55 Gy was associated with supraventricular tachyarrhythmia; right coronary artery volume receiving 25 Gy was associated with bradyarrhythmia; and left main coronary artery volume receiving 5 Gy was associated with ventricular tachyarrhythmia or asystole.<\/p>\n “These observations support continued fine mapping of cardiac substructure dose limits by considering cardiac physiological and pathophysiological mechanisms of disease,” the authors write.<\/p>\n Several authors disclosed ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text<\/a><\/p>\n