All-cause dementia risk greater for those with treated and untreated hypertension compared with healthy controls<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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WEDNESDAY, Aug. 14, 2024 (HealthDay News) — Individuals with treated hypertension have a reduced risk for Alzheimer dementia (AD) compared with those with untreated hypertension, according to research published online Aug. 14 in Neurology<\/em>.<\/p>\n Matthew J. Lennon, M.D., from the University of New South Wales in Sydney, and colleagues examined whether previous hypertension or antihypertensive use modifies AD or non-AD (all-cause dementia) risk in late life in an individual participant data meta-analysis that included community-based longitudinal studies of aging. The risks for developing AD and non-AD were examined as the main outcomes, while the main exposures were hypertension history\/antihypertensive use and baseline systolic and diastolic blood pressure (BP). The analysis included 31,250 participants (mean baseline age, 72 years) from 14 nations.<\/p>\n The researchers found that compared with healthy controls and those with treated hypertension, participants with untreated hypertension had a significantly increased risk for AD (hazard ratios, 1.36 and 1.42, respectively). Both those with treated and untreated hypertension had greater non-AD risk compared with healthy controls (hazard ratios, 1.29 and 1.69, respectively), with no difference seen between the treated and untreated groups. In an analysis restricted to those with five-year follow-up, baseline BP had a significant U-shaped relationship with non-AD risk, but there were no other relationships seen between baseline BP and AD or non-AD risk.<\/p>\n “Throughout late life those with treated hypertension had a lower risk of AD compared with those with untreated hypertension, suggesting that antihypertensive use should be part of any AD prevention strategy even in late life,” the authors write.<\/p>\n Several authors disclosed ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n