For mixture of six urinary metals, adjusted hazard ratio for interquartile range increase was 1.29 and 1.66 for CVD, mortality<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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WEDNESDAY, Aug. 7, 2024 (HealthDay News) — Urinary metal levels are associated with an increased risk for cardiovascular disease (CVD) and all-cause mortality, according to a study published online Aug. 1 in Circulation<\/em>.<\/p>\n Irene Martinez-Morata, M.D., Ph.D., from the Columbia University Mailman School of Public Health in New York City, and colleagues examined the prospective association of urinary metals with incident CVD and all-cause mortality in the racially diverse Multi-Ethnic Study of Atherosclerosis. Data were included for 6,599 participants with urinary metals available at baseline (2000 to 2001) who were followed through December 2019.<\/p>\n The researchers found that 1,162 participants developed CVD and 1,844 participants died during follow-up. Comparing the highest with the lowest quartiles, the hazard ratios for incident CVD and all-cause mortality were 1.25 and 1.68 for cadmium; 1.20 and 1.16 for tungsten; 1.32 and 1.32 for uranium; 1.24 and 1.37 for cobalt; 1.42 and 1.50 for copper; and 1.21 and 1.38 for zinc, respectively, in models adjusted by behavioral and clinical indicators. For cadmium and copper, a positive linear dose-response was seen with both end points. The adjusted hazard ratios for an interquartile range increase in the mixture of these urinary metals and 10-year survival probability difference for incident CVD and all-cause mortality were 1.29 and \u00e2\u0088\u00921.1 percent and 1.66 and \u00e2\u0088\u00922.0 percent, respectively.<\/p>\n “These findings support the role of metals as emerging and preventable risk factors for CVD and all-cause mortality and can inform the development of novel preventive strategies to improve cardiovascular health by mitigating the adverse effects of metals,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n