Increased risk for NAION seen among participants with T2D, overweight\/obesity receiving semaglutide versus non-GLP1-RA meds<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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WEDNESDAY, July 3, 2024 (HealthDay News) — Semaglutide is associated with nonarteritic anterior ischemic optic neuropathy (NAION) among patients with type 2 diabetes (T2D) and those with overweight\/obesity, according to a study published online July 3 in JAMA Ophthalmology<\/em>.<\/p>\n Jimena Tatiana Hathaway, M.D., M.P.H., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues examined the potential association between semaglutide and the risk for NAION in a retrospective matched cohort study. Data were obtained for 16,827 patients, including 710 with T2D (194 prescribed semaglutide; 516 prescribed non-glucagon like peptide 1 receptor agonist [GLP1-RA] antidiabetic medications) and 979 with overweight or obesity (361 prescribed semaglutide; 618 prescribed non-GLP1 RA weight-loss medications).<\/p>\n The researchers observed 17 and six NAION events in patients prescribed semaglutide and non-GLP1 RA medications, respectively. Over 36 months, the cumulative incidence of NAION among patients with T2D was 8.9 and 1.8 percent for the semaglutide and non-GLP1 RA cohorts, respectively. The risk for NAION was significantly higher for patients receiving semaglutide (hazard ratio, 4.28) in a Cox proportional hazards regression model. Among patients with overweight or obesity, there were 20 and three NAION events in the semaglutide and non-GLP1 RA cohorts, respectively. The cumulative incidence of NAION over 36 months was 6.7 and 0.8 percent for semaglutide and non-GLP1 RA medications, respectively, with a higher risk for NAION seen for patients prescribed semaglutide (hazard ratio, 7.64).<\/p>\n “There has been no prior mention, to our knowledge, of an increased risk of NAION in association with semaglutide, and our study does not inform a mechanism to link semaglutide to NAION,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n