Significantly lower risk of major adverse cardiovascular events, all-cause mortality seen in metabolic surgery group<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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FRIDAY, June 28, 2024 (HealthDay News) — Metabolic surgery is associated with significantly lower risk of major adverse cardiovascular events (MACE) compared with nonsurgical management among patients with moderate-to-severe obstructive sleep apnea (OSA) and obesity, according to a study published online June 21 in the Journal of the American College of Cardiology<\/em>.<\/p>\n Ali Aminian, M.D., from the Bariatric and Metabolic Institute at the Cleveland Clinic, and colleagues examined the long-term relationship between metabolic surgery and incident MACE in patients with OSA and obesity (body mass index, 35 to 70 kg\/m2<\/sup>). Patients who underwent metabolic surgery were matched with a nonsurgical control group using overlap weighting methods. Data were included for 970 patients in the metabolic surgery group and 12,687 in the nonsurgical group, with median follow-up of 5.3 years.<\/p>\n The researchers found that the mean between-group difference in body weight at 10 years was 26.6 kg (19.3 percent). The 10-year cumulative incidence of MACE was 27.0 and 35.6 percent in the metabolic surgery and nonsurgical groups, respectively (adjusted hazard ratio, 0.58). The 10-year cumulative incidence of all-cause mortality was 9.1 and 12.5 percent in the metabolic surgery and nonsurgical groups, respectively (adjusted hazard ratio, 0.63).<\/p>\n “In select patients, bariatric surgery is a lifesaving treatment,” Aminian said in a statement. “The MOSAIC study suggests the presence of a dose-dependent response between the amount of weight loss and cardiovascular benefits in patients with obstructive sleep apnea; the greater the weight loss, the lower the risk of heart complications.”<\/p>\n Several authors disclosed ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n