{"id":110159,"date":"2024-06-14T00:00:00","date_gmt":"2024-06-14T00:00:00","guid":{"rendered":"https:\/\/medgoo.com\/index.php\/2024\/06\/14\/midlife-inflammation-tied-to-slowing-of-gait-speed-in-later-life\/"},"modified":"2024-06-14T00:00:00","modified_gmt":"2024-06-14T00:00:00","slug":"midlife-inflammation-tied-to-slowing-of-gait-speed-in-later-life","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2024\/06\/14\/midlife-inflammation-tied-to-slowing-of-gait-speed-in-later-life\/","title":{"rendered":"Midlife Inflammation Tied to Slowing of Gait Speed in Later Life"},"content":{"rendered":"<h3>\n<p>Findings even among otherwise healthy adults and regardless of race or socioeconomic disadvantage<\/p>\n<\/h3>\n<p><b>By Lori Solomon HealthDay Reporter<\/b><\/p>\n<p><b><\/b><\/p>\n<p>FRIDAY, June 14, 2024 (HealthDay News) &#8212; Inflammation in midlife may contribute to clinically meaningful late-life slowing of gait speed, according to a study published online June 12 in the\u00a0<em>Journal of the American Geriatrics Society<\/em>.<\/p>\n<p>Kirby G. Parker, M.D., from the University of Mississippi Medical Center in Jackson, and colleagues examined the relationship between midlife inflammation and late-life mobility, along with the influences of chronic health conditions, race, and social determinants of health (SDoH). Analysis included 4,758 community-dwelling participants with high-sensitivity C-reactive protein (hsCRP) measured in midlife at study visit 2 (1990\u00e2\u0080\u00931992; 47 to 68 years); at visit 4 (1996 to 1998; 53 to 74 years); and late-life (visit 5: 2011 to 2013; mean 75 years).<\/p>\n<p>The researchers found that high midlife hsCRP was associated with slower late-life gait speed, even among those without chronic conditions in midlife (\u00e2\u0088\u00924.6 cm\/second). Among those who never experienced obesity, diabetes, or hypertension, sustained high hsCRP was associated with a 20-year slowing of \u00e2\u0088\u009210.0 cm\/second. Findings were similar for both Black participants (\u00e2\u0088\u00923.8 cm\/second) and White participants (\u00e2\u0088\u00923.3 cm\/second) per interquartile range of midlife hsCRP. Chronic conditions and race had no effect modifications throughout. In all participants, worse SDoH was associated with higher inflammation and slower gait speed.<\/p>\n<p>&#8220;Regular monitoring of inflammation during wellness visits and other preventative programs may be warranted for all people, adding value alongside other common chronic condition measures,&#8221; the authors write.<\/p>\n<p>One author disclosed ties to the pharmaceutical industry.<\/p>\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgs.18978\">Abstract\/Full Text\u00a0(subscription or payment may be required)<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2024 <a href=\"https:\/\/consumer.healthday.com\/\" target=\"_new\" rel=\"noopener\">HealthDay<\/a>. All rights reserved.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Findings even among otherwise healthy adults and regardless of race or socioeconomic disadvantage<\/p>\n","protected":false},"author":6,"featured_media":110160,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-110159","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/110159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=110159"}],"version-history":[{"count":0,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/110159\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/110160"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=110159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=110159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=110159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}