Meta-analysis reveals gastric emptying delay of \u223c36 minutes<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
<\/b><\/p>\n
WEDNESDAY, June 12, 2024 (HealthDay News) — Glucagon-like peptide-1 receptor agonist (GLP-1 RA) medications do slow gastric emptying but not by enough to warrant discontinuing medications before surgery, according to a review published in the June issue of the\u00a0American Journal of Gastroenterology<\/em>.<\/p>\n Brent Hiramoto, M.D., from Brigham and Women’s Hospital in Boston, and colleagues conducted a systematic review and meta-analysis to provide quantitative measures of gastric emptying relevant to mechanisms of weight loss and to periprocedural management of GLP-1 RAs.<\/p>\n For the five studies (247 patients) that utilized gastric emptying scintigraphy, the researchers found that mean T1\/2\u00a0<\/sub>was 138.4 minutes for GLP-1 RAs versus 95.0 minutes for placebo, with a pooled mean difference of 36.0 minutes (I<\/em>2<\/sup> = 79.4 percent). For the 10 studies (411 patients) that used the acetaminophen absorption test, there was no significant delay in gastric emptying measured by Tmax<\/sub>, area under the curve (AUC)4hour<\/sub>, and AUC5hour<\/sub>\u00a0with GLP-1 RAs. There was no impact on gastric emptying for the type of GLP-1 RA, mechanism of action, or treatment duration.<\/p>\n “Based on our study, we recommend that guidelines be updated with the following precautions for GLP-1 RA users undergoing endoscopic procedures: continue therapy, follow a liquid-only diet the day prior, and adhere to standard pre-anesthesia fasting,” Hiramoto said in a statement. “Until more data on solid diets is available, a conservative approach with a liquid diet while continuing therapy is advisable.”<\/p>\n One author disclosed ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text\u00a0(subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n