Higher CVD mortality risk seen for men with baseline testosterone concentration below 5.3 nmol\/L<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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MONDAY, May 13, 2024 (HealthDay News) — The risk for all-cause mortality is increased for men with low testosterone, high luteinizing hormone, or very low estradiol, according to a review published online May 14 in the Annals of Internal Medicine<\/em>.<\/p>\n Bu B. Yeap, M.B.B.S., Ph.D., from the University of Western Australia in Perth, and colleagues conducted a systematic review to clarify associations of sex hormones with mortality and cardiovascular disease (CVD). Nine studies provided individual participant data (IPD; 255,830 participant-years), and summary estimates were provided by 11 studies (24,109 participants).<\/p>\n The researchers found that two-stage random-effects IPD meta-analyses indicated higher all-cause mortality for men with baseline testosterone concentrations below 7.4 nmol\/L, luteinizing hormone concentrations above 10 IU\/L, or estradiol concentrations below 5.1 pmol\/L; higher CVD mortality risk was seen for those with testosterone concentrations below 5.3 nmol\/L. Lower sex hormone-binding globulin concentration was associated with lower all-cause and CVD mortality (adjusted hazard ratios, 0.85 and 0.81, respectively, for quintile 1 versus 5). Higher risk for all-cause and CVD mortality was seen for men with lower baseline dihydrotestosterone concentrations (adjusted hazard ratios, 1.19 and 1.29, respectively, for quintile 1 versus 5); risk increased with concentrations above 2.45 nmol\/L. An increased risk for incident CVD events was seen for men with dihydrotestosterone concentrations below 0.59 nmol\/L.<\/p>\n “We found that the testosterone concentration below which men had higher risk for all-cause mortality was 7.4 nmol\/L (213 ng\/dL),” the authors write. “This adds to information on reference ranges based on distributions of testosterone in selected samples of healthy men.”<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n