Score based on high-resolution manometry<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
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MONDAY, May 6, 2024 (HealthDay News) — A novel high-resolution manometry (HRM) score can stratify the risk and severity of gastroesophageal reflux disease (GERD), according to a study published online March 27 in the\u00a0UEG Journal<\/em>.<\/p>\n Stefano Siboni, M.D., from IRCCS Policlinico San Donato in Milan, and colleagues built and externally validated a manometric score (Milan Score) to stratify the risk and severity of the disease in patients undergoing HRM for suspected GERD. The analysis included 295 consecutive patients undergoing HRM and pH-study for persistent typical or atypical GERD symptoms.<\/p>\n The researchers report that straight leg raise response and evaluating esophagogastric junction subtype 3 had the highest impact on the score (odds ratios, 18.20 and 3.87, respectively). The external validation cohort of 233 patients showed the model had a corrected Harrel c-index of 0.90. There was good calibration observed, with a model-fitting optimism adjusted calibration slope of 0.93 and an integrated calibration index of 0.07.<\/p>\n “A novel HRM score for GERD diagnosis has been validated,” the authors write. “We anticipate the Milan Score to be a useful screening tool to predict pathologic GERD, to stratify disease severity, and eventually make the diagnostic pathway more efficient and GERD treatment more precise and personalized.”<\/p>\n