Findings persist with ulcerative colitis but not Crohn disease<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
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WEDNESDAY, April 3, 2024 (HealthDay News) — An increased serum level of 25-hydroxyvitamin D\u00a0(25[OH]D) is independently associated with a lower risk for bowel resection with inflammatory bowel disease (IBD), according to a study published online March 25 in the\u00a0International Journal of Surgery<\/em>.<\/p>\n Lintao Dan, from the Third Xiangya Hospital of Central South University in Changsha, China, and colleagues examined the association between serum vitamin D levels and the risk for bowel resection in individuals with IBD. The analysis included 5,474 individuals with IBD followed for a mean 13.1 years.<\/p>\n The researchers found that compared with participants with vitamin D deficiency, nondeficient participants showed a significantly reduced bowel resection risk in IBD (hazard ratio [HR], 0.72), Crohn disease (CD; HR, 0.74), and ulcerative colitis (UC; HR, 0.73). For the highest versus lowest quintiles of 25(OH)D level, there was a 34 percent reduced risk for bowel resection with IBD and a 46 percent reduced risk with UC; these findings were statistically significant. However, there were no significant associations for risk for bowel resection in CD. Linear dose-response associations were seen using the restricted cubic spline curve.<\/p>\n “Vitamin D deficiency is a risk factor for bowel resection in individuals with IBD, and may be an effective metric in predicting and risk-screening surgical events,” the authors write.<\/p>\n