Significantly longer progression-free and overall survival seen in patients with previously untreated locally advanced or metastatic urothelial carcinoma<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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FRIDAY, March 8, 2024 (HealthDay News) — For patients with previously untreated locally advanced or metastatic urothelial carcinoma, enfortumab vedotin and pembrolizumab yield significantly better survival than chemotherapy, according to a study published in the March 7 issue of the New England Journal of Medicine<\/em>.<\/p>\n Thomas Powles, M.D., from Queen Mary University of London, and colleagues conducted a phase 3, randomized trial to compare the efficacy and safety of enfortumab vedotin and pembrolizumab with platinum-based chemotherapy among patients with previously untreated locally advanced or metastatic urothelial carcinoma. A total of 886 patients were randomly assigned to receive three-week cycles of enfortumab vedotin and pembrolizumab (442 patients) or gemcitabine and either cisplatin or carboplatin (chemotherapy group; 444 patients).<\/p>\n The median duration of follow-up for survival was 17.2 months as of Aug. 8, 2023. The researchers found that the enfortumab vedotin-pembrolizumab group had significantly longer progression-free survival than the chemotherapy group (median, 12.5 versus 6.3 months; hazard ratio for disease progression or death, 0.45), as well as longer overall survival (median, 31.5 versus 16.1 months; hazard ratio for death, 0.47). Treatment-related adverse events of grade 3 or higher occurred in 55.9 and 69.5 percent of patients in the enfortumab vedotin-pembrolizumab and chemotherapy groups, respectively.<\/p>\n “This trial showed a significant survival benefit of enfortumab vedotin and pembrolizumab as compared with chemotherapy in patients with previously untreated locally advanced or metastatic urothelial carcinoma,” the authors write.<\/p>\n The study was funded by Astellas and Seagen, the manufacturers of enfortumab, and Merck, the manufacturer of pembrolizumab.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n