Incremental cost-effectiveness ratios were $126,000 and $281,000 per QALY for two simulation models from a societal perspective<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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MONDAY, Jan. 22, 2024 (HealthDay News) — Gene therapy for sickle cell disease (SCD) below $2 million is likely to be cost-effective, according to a study published online Jan. 23 in the Annals of Internal Medicine<\/em>.<\/p>\n Anirban Basu, Ph.D., from The Comparative Health Outcomes, Policy & Economics Institute at the University of Washington in Seattle, and colleagues examined the cost-effectiveness of gene therapy for SCD and its value-based prices in a comparative modeling analysis conducted across two independently developed simulation models (University of Washington Model for Economic Analysis of Sickle Cell Cure [UW-MEASURE] and Fred Hutchinson Institute Sickle Cell Disease Outcomes Research and Economics Model [FH-HISCORE]) among persons eligible for gene therapy.<\/p>\n The researchers estimated incremental cost-effectiveness ratios of $193,000 and $427,000 per quality-adjusted life year (QALY) with UW-MEASURE and FH-HISCORE, respectively, under the health care sector perspective, and at an assumed $2 million price for gene therapy. From the societal perspective, the corresponding estimates were $126,000 and $281,000 per QALY. Acceptable value-based prices ranged from $1 million to $2.5 million from a societal perspective, depending on the use of alternative effective metrics or equity-informed threshold values. The results were sensitive to costs of myeloablative conditioning before gene therapy, the effect on caregiver quality of life, and the impact of gene therapy on long-term survival.<\/p>\n “Our results suggest that gene therapy for SCD can bring substantial benefits to this population and provide evidence for the proper reimbursement level for these therapies by Centers for Medicare & Medicaid Services,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n