NLR levels differ significantly among healthy patients and those with interstitial cystitis\/bladder pain syndrome, overactive bladder<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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MONDAY, Jan. 8, 2024 (HealthDay News) — Serum neutrophil-to-lymphocyte ratio (NLR) can help differentiate interstitial cystitis\/bladder pain syndrome (IC\/BPS) from overactive bladder (OAB), according to a study published online Nov. 8 in BMC Urology<\/em>.<\/p>\n Hanwei Ke, from Peking University People’s Hospital in Beijing, and colleagues conducted a retrospective analysis involving 70 women diagnosed with IC\/BPS, 20 diagnosed with OAB, and a randomly selected cohort of 150 healthy women (normal). All participants underwent a comprehensive panel of blood tests, and the NLR was determined.<\/p>\n The researchers observed significant differences in the NLR levels among the IC\/BPS, normal, and OAB groups. Notably divergent NLR levels were demonstrated in Hunner type IC (HIC) compared with non-Hunner type IC (NHIC) within the IC\/BPS group. Positive correlations were also seen between NLR and nighttime voids, the Interstitial Cystitis Problem Index, Interstitial Cystitis Symptom Index, Pelvic Pain and Urgency\/Frequency questionnaire (PUF), and PUF Symptom Scale. The area under the receiver operating characteristic curve analysis for NLR was 0.765 and 0.707 for distinguishing IC\/BPS from the normal group and IC from OAB, respectively, and was 0.723 for differentiating HIC and NHIC patients.<\/p>\n “Our study underscores the link between heightened NLR and the symptomatology and onset of IC\/BPS, underscoring the potential of NLR as a diagnostic marker for IC\/BPS,” the authors write. “Given the ongoing diagnostic debates surrounding IC\/BPS, NLR can offer valuable support in the diagnostic process.”<\/p>\n