{"id":105295,"date":"2023-11-09T00:00:00","date_gmt":"2023-11-09T00:00:00","guid":{"rendered":"https:\/\/medgoo.com\/index.php\/2023\/11\/09\/one-day-induction-of-xr-buprenorphine-feasible-for-fentanyl-use-in-oud\/"},"modified":"2023-11-10T19:10:09","modified_gmt":"2023-11-10T19:10:09","slug":"one-day-induction-of-xr-buprenorphine-feasible-for-fentanyl-use-in-oud","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2023\/11\/09\/one-day-induction-of-xr-buprenorphine-feasible-for-fentanyl-use-in-oud\/","title":{"rendered":"One-Day Induction of XR Buprenorphine Feasible for Fentanyl Use in OUD"},"content":{"rendered":"<h3>\n<p>Rapid induction to extended-release buprenorphine 300-mg injection feasible and well tolerated for those using fentanyl<\/p>\n<\/h3>\n<p><b>By Elana Gotkine HealthDay Reporter<\/b><\/p>\n<p><b><\/b><\/p>\n<p>WEDNESDAY, Nov. 8, 2023 (HealthDay News) &#8212; For individuals with opioid use disorder (OUD) using fentanyl, a one-day induction of extended-release buprenorphine is a feasible treatment approach, according to a study published online Nov. 8 in the <em>American Journal on Addiction<\/em>.<\/p>\n<p>John J. Mariani, M.D., from the New York State Psychiatric Institute in New York City, and colleagues conducted a secondary analysis of results grouped by fentanyl use status for an open-label study with rapid induction of extended-release buprenorphine in the inpatient research unit. A single 4-mg dose of transmucosal buprenorphine (BUP-TM) was administered to eligible participants, followed by an extended-release buprenorphine 300-mg injection (BUP-XR) after approximately one hour. Follow-up was continued to six months in an extension study (six monthly injections).<\/p>\n<p>All 19 participants with fentanyl-positive urine samples (FEN+) received BUP-TM, 17 received BUP-XR, 13 chose to receive a second BUP-XR, and 10 received all six scheduled injections. All seven participants with fentanyl-negative urine samples (FEN\u00e2\u0088\u0092) received BUP-TM and BUP-XR, four elected to receive a second injection, and two received all six injections. The FEN+ and FEN\u00e2\u0088\u0092 groups had similar induction-day clinical opioid withdrawal scale (COWS) scores. Within 24 hours of BUP-XR injection, mean COWS scores fell to below 5 in the FEN+ group.<\/p>\n<p>&#8220;Fentanyl and other synthetic opioids are the leading cause of overdose deaths in the United States and rapid induction to BUP-XR injection may be an important potential treatment option for this at-risk population,&#8221; the authors write.<\/p>\n<p>Several authors disclosed ties to Indivior, which funded the study.<\/p>\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajad.13484\">Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2023 <a href=\"https:\/\/consumer.healthday.com\/\" target=\"_new\" rel=\"noopener\">HealthDay<\/a>. All rights reserved.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rapid induction to extended-release buprenorphine 300-mg injection feasible and well tolerated for those using fentanyl<\/p>\n","protected":false},"author":6,"featured_media":105346,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-105295","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/105295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=105295"}],"version-history":[{"count":1,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/105295\/revisions"}],"predecessor-version":[{"id":105345,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/105295\/revisions\/105345"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/105346"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=105295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=105295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=105295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}