Plasma with neutralizing antibody titer of at least 1:160 reduces mortality at 28 days versus standard care<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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MONDAY, Oct. 30, 2023 (HealthDay News) — For patients with COVID-19-induced acute respiratory distress syndrome (ARDS), administration of plasma from convalescent donors with a neutralizing antibody titer of at least 1:160 within five days after initiation of invasive mechanical ventilation reduces mortality at 28 days, according to a study published online Oct. 26 in the New England Journal of Medicine<\/em>. The study was published to coincide with the annual congress of the European Society of Intensive Care Medicine, held from Oct. 21 to 25 in Milan.<\/p>\n Beno \u00aet Misset, M.D., from\u00c2\u00ad the University Hospital of Li \u00a8ge in Belgium, and colleagues randomly assigned adults with COVID-19-induced ARDS who had been receiving invasive mechanical ventilation for less than five days to receive convalescent plasma with a neutralizing antibody titer of at least 1:320 or standard care alone (237 and 238 patients, respectively). Due to a shortage of convalescent plasma, 17.7 percent of patients in the convalescent-plasma group received a neutralizing antibody titer of 1:160.<\/p>\n Glucocorticoids were administered to 98.1 percent of the patients. The researchers found that mortality was 35.4 and 45.0 percent in the convalescent-plasma and standard-care groups, respectively, at day 28. This effect was mainly seen in patients who underwent randomization 48 hours or less after initiation of invasive mechanical ventilation in a prespecified analysis. There was no substantial difference noted between the groups in serious adverse events.<\/p>\n “We believe our trial has a good potential for generalizability to most patients with COVID-19-induced ARDS because almost 50 percent of such patients were included in the centers during their participation in the trial,” the authors write.<\/p>\n Several authors disclosed ties to industry.<\/p>\n Abstract\/Full Text<\/a><\/p>\n