Higher treatment response rate at one and three months seen for children with nocturnal enuresis with lower first-morning urine osmolality<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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WEDNESDAY, Oct. 4, 2023 (HealthDay News) — Children with nocturnal enuresis (NE) with a lower first-morning urine osmolality (Uosm) have higher treatment response rates, according to a study published in the September issue of Investigative and Clinical Urology<\/em>.<\/p>\n Gwon Kyeong Lee, from the Pusan National University School of Medicine in South Korea, and colleagues enrolled 99 children with NE in a retrospective study and categorized them according to first-morning Uosm results into a low Uosm group (<800 mOsm\/L; 38 cases) or a high Uosm group (\u00e2\u0089\u00a5800 mOsm\/L; 61 cases). Baseline parameters were obtained, and all cases were administered standard urotherapy and pharmacological treatment. At one and three months after treatment initiation, enuresis frequency and response rates were analyzed.<\/p>\n The researchers found that the level of first-morning Uosm was 997.1 \u00c2\u00b1 119.6 and 600.9 \u00c2\u00b1 155.9 mOsm\/L in the high and low Uosm groups, respectively. The low Uosm group had significantly greater first-morning voided volume and total voided volume. A response rate of \u00e2\u0089\u00a550 percent was seen for a significantly higher percentage of children in the low Uosm group at one month (50.0 versus 24.6 percent) and three months (63.2 versus 36.1 percent).<\/p>\n “First-morning Uosm testing can be performed easily, safely, and cost-effectively even on children with NE,” the authors write. “This study showed that NE children with lower first-morning Uosm responded better to urotherapy and pharmacological therapy.”<\/strong><\/p>\n