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TUESDAY, Sept. 11, 2018 (HealthDay News) — A single multiorgan donor transmitted breast cancer to four transplant recipients, according to a case report published recently in the American Journal of Transplantation<\/i>.<\/p>\n
Yvette A.H. Matser, from the VU University Medical Center in the Amsterdam, and colleagues reported four cases of breast cancer transmission to transplant recipients from a single organ donor. The donor had no relevant medical history and donated her kidneys, lungs, liver, and heart. The heart recipient died five months later from sepsis.<\/p>\n
The authors note that with 16 months to six years after transplantation, the other four recipients developed donor-derived breast cancer, which was proven by DNA microsatellite. As a result of the donor-derived breast cancer, the double-lung recipient, left-kidney recipient, and liver recipient died. After diagnosis of the breast cancer in the right-kidney recipient, the patient underwent transplant nephrectomy, his immunosuppression was stopped, chemotherapy was initiated, and despite having widely metastasized disease he achieved complete remission.<\/p>\n
“This extraordinary case points out the often fatal consequences of donor-derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission,” the authors write.<\/p>\n
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